特定型别与降解型肺炎球菌的血清学关系。
SEROLOGICAL RELATIONSHIPS OF TYPE-SPECIFIC AND DEGRADED PNEUMOCOCCI.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1926 Jan 1;43(1):107-17. doi: 10.1084/jem.43.1.107.
Abstract
- Immune sera prepared with the degraded or variant forms of pneumococci (R strains) are similar in their reactions to sera prepared with the protein or cell solutions of pneumococci. They contain antibodies reactive with the protein of all types of pneumococci, but no antibodies reactive with the type-specific substances. 2. Pneumococci of the variant or R form, regardless of type derivation, are serologically identical and have the antigenic characteristics of pneumococcus protein. They evoke the species-specific and not the type-specific antibodies. 3. Antipneumococcus sera obtained by immunization with S strains may contain species-specific antibodies in addition to those which are type-specific. Each kind of antibody can be removed separately from these sera by selective absorption with the R or S strains of pneumococci.
摘要
用降解或变异形式的肺炎球菌（R 型）制备的免疫血清与用肺炎球菌的蛋白质或细胞溶液制备的血清在反应上相似。它们含有与所有类型肺炎球菌的蛋白质反应的抗体，但没有与型特异性物质反应的抗体。
无论其来源如何，变异型或 R 型肺炎球菌在血清学上是相同的，具有肺炎球菌蛋白质的抗原特征。它们引起的是种特异性抗体，而不是型特异性抗体。
用 S 型菌株免疫获得的抗肺炎球菌血清除了具有型特异性抗体外，还可能含有种特异性抗体。可以用 R 或 S 型肺炎球菌菌株从这些血清中分别去除每种抗体。
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