维生素 A 缺乏与化生。
VITAMIN A DEFICIENCY AND METAPLASIA.
机构信息
Department of Pathology, School of Medicine, Western Reserve University, Cleveland.
出版信息
J Exp Med. 1927 Oct 31;46(5):699-707. doi: 10.1084/jem.46.5.699.
Of nineteen rats on a complete diet (Group III, Diet + C. L. O.), none showed foci of squamous keratinizing epithelium in abnormal situations. Of twenty-six rats on a diet deficient in vitamins A and D (Group I, Diet-A-D), twenty-three showed metaplastic changes of varying degree in one or more organs; the metaplasia was of columnar, cuboidal, and transitional epithelium to the squamous keratinizing type. Of eighteen rats on a diet deficient in vitamin A alone (Group II, Diet-A), seventeen showed epithelial metaplasia similar to that of Group I in one or more organs. In Groups I (Diet-A-D) and II (Diet-A) the changes occurred in one or more of the following organs: trachea, large bronchi, small bronchi or bronchioles in lung, posterior nares, accessory salivary glands of base of tongue, paraocular, submaxillary, sublingual, and parotid glands, renal pelvis, ureter, and bladder. The metaplastic changes were as extensive in the rats of Group II on a diet deficient in vitamin A alone as in those of Group I which received a diet deficient in vitamins A and D.
在完全饮食（第三组，饮食+C.L.O.）的 19 只大鼠中，没有一只在异常情况下出现鳞状角质化上皮的焦点。在缺乏维生素 A 和 D 的饮食（第一组，饮食-A-D）的 26 只大鼠中，有 23 只在一个或多个器官中出现不同程度的化生改变；化生类型为柱状、立方和过渡上皮到鳞状角质化。在单独缺乏维生素 A 的饮食（第二组，饮食-A）的 18 只大鼠中，有 17 只在一个或多个器官中出现类似于第一组的上皮化生。在第一组（饮食-A-D）和第二组（饮食-A）中，变化发生在一个或多个以下器官中：气管、大支气管、肺中小支气管或细支气管、后鼻孔、舌底副唾液腺、眼周、颌下、舌下和腮腺、肾盂、输尿管和膀胱。在单独缺乏维生素 A 的饮食的第二组大鼠中，化生改变与接受缺乏维生素 A 和 D 的饮食的第一组大鼠一样广泛。
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