Laboratory Division, Montefiore Hospital, New York.
J Exp Med. 1932 Jan 1;55(1):109-19. doi: 10.1084/jem.55.1.109.
Normal adult Wistar rats (non-carrier stock) are readily infected with Bartonella muris and develop a severe anemia if large amounts of infecting material are used. The normal adult rat of Wistar stock possesses a relatively high natural resistance to spontaneous infection with this organism. Bilateral suprarenalectomy in Wistar rats lowers the natural resistance to a subsequent infection with Bartonella muris. This procedure does not alter the type of tissue response to the virus but lowers the natural resistance of the rat to toxic effects of the infection. The acquired immunity to Bartonella muris conferred by a first infection is not broken down by subsequent suprarenalectomy. The mechanisms of acquired and natural resistance are dependent on different physiological processes in the organism and are not merely quantitative variations of the same process as is generally assumed.
正常成年 Wistar 大鼠（非携带品系）易感染伯氏疏螺旋体鼠亚种，如果使用大量感染材料，会发展为严重贫血。正常 Wistar 大鼠对这种生物体的自发性感染具有相对较高的天然抵抗力。双侧肾上腺切除术降低了 Wistar 大鼠对随后感染伯氏疏螺旋体鼠亚种的天然抵抗力。该程序不会改变组织对病毒的反应类型，但会降低大鼠对感染毒性作用的天然抵抗力。由初次感染引起的对伯氏疏螺旋体鼠亚种的获得性免疫不会因随后的肾上腺切除术而被破坏。获得性和天然抵抗力的机制取决于机体中不同的生理过程，而不仅仅是通常假设的同一过程的数量变化。
