Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1928 Jan 31;47(2):235-43. doi: 10.1084/jem.47.2.235.
Bartonella muris appeared in the blood of all white rats, wild rats, Chinese hamster, and mice, from which the spleen was removed, but did not appear in that of splenectomized monkeys, rabbits, or guinea pigs. It has not been possible to transmit B. muris to normal rats, monkeys, rabbits, or guinea pigs, by intraperitoneal, intradermal, or intravenous injection of blood containing B. muris from splenectomized rats. In two instances an acute orchitis was induced in normal rats by injection directly into the testicle of blood or saline suspensions of the liver of splenectomized rats. The intracorpuscular elements occasionally identified as B. muris or as having appeared as a result of the inoculation. The acute orchitis of rats was transferable to normal rats in series. From the testicular tissue, as well as directly from the blood of a splenectomized rat, there was isolated in pure culture a microorganism which induced in the testicles of normal rats an acute orchitis such as resulted from inoculation of the blood or liver suspensions of splenectomized rats. While a few inclusions were found in the erythrocytes of some of the animals, their number was so small and their occurence so infrequent that they could not be definitely identified as B. muris. In morphological features the cultural forms of the microorganism isolated resemble B. muris. The organism found in the testicular tissues, however, is considerably coarser than B. muris and takes a deeper stain. Immunological study failed to settle the question of the relation between B. muris and the cultivated organism, which is provisionally called Bacterium murium. Bartonella muris, Bartonella bacilliformis, and Grahamella talpae have characteristic individual morphological features.
贝氏巴尔通体出现在所有切除脾脏的大白鼠、野鼠、中国仓鼠和小鼠的血液中，但不出现在切除脾脏的猴子、兔或豚鼠的血液中。将含有切除脾脏大鼠血液的贝氏巴尔通体通过腹腔内、皮内或静脉内注射接种给正常大鼠、猴子、兔或豚鼠，均未能使其感染贝氏巴尔通体。有两例，将切除脾脏大鼠肝脏的血液或盐水混悬液直接注入正常大鼠睾丸，引起急性睾丸炎。偶尔在胞内可辨认出贝氏巴尔通体或接种后出现的类似物。大鼠的急性睾丸炎可在正常大鼠中连续传递。从睾丸组织以及直接从切除脾脏大鼠的血液中，分离出一种纯培养的微生物，该微生物在正常大鼠的睾丸中引起类似于接种切除脾脏大鼠的血液或肝脏混悬液所致的急性睾丸炎。虽然在一些动物的红细胞中发现了少量包涵体，但数量很少，出现频率也很低，不能明确将其鉴定为贝氏巴尔通体。在形态学特征方面，分离出的微生物的培养形态与贝氏巴尔通体相似。然而，在睾丸组织中发现的生物体比贝氏巴尔通体粗糙得多，且染色更深。免疫学研究未能确定贝氏巴尔通体与该培养的生物体之间的关系，该生物体暂被称为贝氏巴尔通体鼠亚种。贝氏巴尔通体、杆菌状巴尔通体和兔巴尔通体具有独特的个体形态学特征。
