Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1929 Feb 28;49(3):361-86. doi: 10.1084/jem.49.3.361.
In 87 rabbits, some of which received intravenously at various intervals small, and some large, doses of killed staphylococci, the following findings were obtained. 1. There occurred a hyperplasia of lymph nodes, spleen and thymus, that is to say, a status thymicolymphaticus. This phenomenon is explained as due to immediate local irritation caused by bacteria and their products and by certain "toxins" partly of exogenous, partly of endogenous, origin. 2. The lymphocytosis which appeared was parallel in time and degree with the hyperplasia of the peripheral lymph nodes (axillary, popliteal and cervical lymph nodes) and probably originated in the pseudo-secondary nodules of these nodes. 3. There occurred intense mesenchymal reaction in the vascular connective tissue of the lungs, liver and spleen and after large doses slighter ones in adrenals, kidneys and heart. These reactions correspond with Oeller's adventitial reactions and Siegmund's intima proliferations. In the interstitial tissue of these organs as well as in the walls of the minor vessels proliferations of cells, partly of the type of lymphocytes and plasma cells, partly of that of histiocytes and reticulo-endothelial cells, appeared, which, after large doses, were mixed with many giant cells of Langerhans' type. After small doses lymphocytes and plasma cells predominated, after large doses histiocytes and reticulo-endothelial cells. Because these reactions occurred immediately after the first injection, they can be regarded as primary reactions of the organism to bacteria and their products.
在 87 只兔子中，一些兔子在不同时间间隔内静脉注射了小剂量和大剂量的已杀死的葡萄球菌，得到了以下发现。1. 淋巴结、脾脏和胸腺发生了增生，也就是说，出现了胸腺淋巴样状态。这种现象被解释为细菌及其产物以及某些“毒素”（部分来自外源性，部分来自内源性）引起的即刻局部刺激所致。2. 出现的淋巴细胞增多与外周淋巴结（腋窝、腘窝和颈淋巴结）的增生在时间和程度上是平行的，可能起源于这些淋巴结的假二级结节。3. 肺、肝和脾的血管结缔组织中发生强烈的间质性反应，大剂量后肾上腺、肾脏和心脏中反应较弱。这些反应与 Oeller 的血管外膜反应和 Siegmund 的内膜增殖相对应。在这些器官的间质组织以及小血管壁中，出现了细胞增殖，部分为淋巴细胞和浆细胞类型，部分为组织细胞和网状内皮细胞类型，大剂量后，还出现了许多朗格汉斯型巨细胞。小剂量后淋巴细胞和浆细胞占优势，大剂量后组织细胞和网状内皮细胞占优势。由于这些反应是在第一次注射后立即发生的，因此可以被视为机体对细菌及其产物的原发性反应。
