Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1929 Apr 30;49(5):727-43. doi: 10.1084/jem.49.5.727.
Specific precipitable substances rich in carbohydrates, containing very little protein and small amounts of a material apparently of fatty nature, have been prepared from the main serological types of the typhoid-paratyphoid groups. The preparations in their present state of purity do not exhibit very pronounced chemical differences in spite of serological dissimilarity. In this respect the results differ from those observed with the polysaccharides of pneumococci. The specificity of the precipitin reactions of these substances parallels in a general way the so called small flaking agglutination. Attempts to separate different fractions from the active substance serologically by means of precipitation with antibody solutions were on the whole unsuccessful. The differences in resistance to the action of acid and alkali were found to be characteristic for various specific carbohydrates.
已经从伤寒副伤寒各血清型中制备出富含碳水化合物、含极少量蛋白质和少量类脂物质的特殊可溶物。尽管血清型不同，这些提纯制剂在化学性质上没有明显的差异。这一点与肺炎球菌多糖的结果不同。这些物质沉淀反应的特异性一般与所谓的小絮状凝集平行。试图用抗体溶液沉淀的方法从活性物质中分离出不同的成分，总的来说是不成功的。各种特异碳水化合物的特点是对酸和碱的作用的抵抗力不同。
