口服肺炎球菌免疫：使用胆汁盐溶解的生物体等，免疫出现时间和剂量。

ORAL IMMUNIZATION AGAINST THE PNEUMOCOCCUS : USE OF BILE SALT DISSOLVED ORGANISMS, ETC., TIME OF APPEARANCE OF IMMUNITY AND DOSAGE.

Bureau of Laboratories, Department of Health, New York, N. Y.

J Exp Med. 1930 Mar 31;51(4):585-607. doi: 10.1084/jem.51.4.585.

Abstract

Feeding heat killed pneumococci grown in milk produces a fair degree of immunity. 2. Feeding acid killed degraded aruvilent organisms produces little protection. 3. Feeding the desiccated, mechanically disrupted organisms creates a high degree of protection. 4. Feeding the Berkefeld filtrate of sodium glycocholate dissolved cells produce a high degree of immunity. 5. A single ingestion of this material equivalent to between 1 and 5 cc. growth is sufficient to protect a rat against 1000 to 10,000 fatal doses. Among rats fed the equivalent of 0.1 cc. an occasional one survives. 6. This degree of protection is present 48 hours after the feeding, and to a smaller extent exists in occasional animals at the end of 24 hours. 7. The treated animals are resistant to subcutaneous as well as intraperitoneal injections. 8. A single ingestion of hydrochloric acid killed pneumococci equivalent to between 1 and 5 cc. growth also protects within 48 hours against 1000 to 10,000 fatal doses intraperitoneally injected. 9. Reference is made to results obtained in preliminary experiments with human beings.

摘要

给牛奶中培养的热死肺炎球菌喂食会产生相当程度的免疫力。
喂食酸杀死的弱化病原体几乎不能提供保护。
喂食干燥、机械破坏的生物体可产生高度保护。
喂食用糖胆酸钠溶解的干燥、机械破坏的生物体可产生高度免疫力。
单次摄入相当于 1 至 5cc 生长量的这种物质足以保护大鼠免受 1000 至 10000 倍致死剂量的侵袭。在摄入相当于 0.1cc 的大鼠中，偶尔有一只存活。
这种保护程度在喂食后 48 小时内存在，在 24 小时结束时，偶尔在动物中存在较小程度的保护。
经过处理的动物对皮下和腹腔注射均有抵抗力。
单次摄入相当于 1 至 5cc 生长量的盐酸杀死肺炎球菌也能在 48 小时内提供保护，免受 1000 至 10000 倍致死剂量的腹腔注射。
提到了初步人体实验的结果。