肺炎球菌 II 型和 III 型的口服免疫接种和大鼠对这些类型的正常抵抗力变异。
ORAL IMMUNIZATION AGAINST PNEUMOCOCCUS TYPES II AND III AND THE NORMAL VARIATION IN RESISTANCE TO THESE TYPES AMONG RATS.
机构信息
Bureau of Laboratories, Department of Health of the City of New York, New York.
出版信息
J Exp Med. 1931 Nov 30;54(6):875-98. doi: 10.1084/jem.54.6.875.
Abstract
- Considerable variation in the resistance of different rats toward Type II pneumococcus has been demonstrated. In general, older rats survive much greater doses than young ones, illustrating the acquisition of a natural partial immunity. The same is true for Type III but the immunity appears somewhat later in life and does not reach the same height. 2. An active immunity can be created against Types II and III in rats by feeding the dead organisms or the Berkefeld filtrate of the bile salt-dissolved cells. This immunity resembles that obtained against Type I in several respects.
摘要
不同大鼠对 II 型肺炎球菌的抵抗力有很大差异。一般来说，年老大鼠比年幼大鼠能耐受更大剂量，这表明它们获得了天然的部分免疫力。III 型也是如此，但这种免疫力出现得稍晚，而且达不到同样的高度。
通过给大鼠喂食死菌或用胆盐溶解细胞的贝氏滤液，可以在大鼠体内产生针对 II 型和 III 型的主动免疫。这种免疫力在几个方面类似于针对 I 型获得的免疫力。
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