The Henry Phipps Institute, University of Pennsylvania, Philadelphia, and the Department of Pathology, Harvard Medical School, Boston.
J Exp Med. 1931 Jan 31;53(2):171-7. doi: 10.1084/jem.53.2.171.
Microscopic studies show the presence of a network of fibrin within the tissues and numerous thrombosed lymphatics at the site of inflammation. Precipitated iron compounds, possibly coagulated horse serum, or particulate matter caught in this fibrinous reticulum will disseminate less readily than trypan blue from the site of inflammation. Trypan blue injected at the periphery of an inflamed area fails to enter the site of inflammation. This failure of penetration is caused by the occlusion of lymphatic vessels and by the presence of a fine network of fibrin in the tissue spaces of the inflamed area. Fixation of foreign substances by the inflammatory reaction is therefore primarily due to mechanical obstruction caused by a network of fibrin and by thrombosed lymphatics at the site of inflammation. There is another phase of the problem which still requires more accurate information. This concerns the relation between exudation from blood vessels and changes in flow of lymph from the inflamed area. Further experiments are being conducted to investigate this question. The reaction of fixation which occurs extremely early in the inflammatory process circumscribes the irritating substance and allows a definite period of time for the leucocytes to assemble for the purpose of phagocytosis. It is through a delicate regulating mechanism of this kind that, to use the expression of Opie (7), "the vital organs are protected at the expense of local injury."
显微镜研究表明，在炎症部位的组织中存在纤维蛋白网络和许多血栓形成的淋巴管。沉淀的铁化合物，可能是凝固的马血清，或在纤维状网状物中捕获的颗粒物质，比从炎症部位扩散的锥蓝更不容易扩散。在炎症区域的外围注射锥蓝，无法进入炎症部位。这种渗透失败是由于淋巴管阻塞以及炎症区域组织间隙中存在细纤维蛋白网络所致。因此，炎症反应对异物的固定主要是由于纤维蛋白网络和炎症部位的血栓淋巴管造成的机械阻塞。还有一个问题的阶段仍然需要更准确的信息。这涉及到血管渗出物与炎症区域淋巴流量变化之间的关系。正在进行进一步的实验来研究这个问题。在炎症过程中极早期发生的固定反应，限制了刺激性物质的范围，并为白细胞聚集以进行吞噬作用提供了明确的时间。正是通过这种微妙的调节机制，用奥皮（Opie）的话来说（7），“以牺牲局部损伤为代价保护重要器官”。
