特定酶对 III 型肺炎球菌感染小鼠的保护作用。
THE PROTECTIVE ACTION OF A SPECIFIC ENZYME AGAINST TYPE III PNEUMOCOCCUS INFECTION IN MICE.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1931 Jun 30;54(1):73-89. doi: 10.1084/jem.54.1.73.
The bacterial enzyme which decomposes the purified capsular polysaccharide of Type III Pneumococcus in vitro also destroys the capsules of the living organisms growing in media and in the animal body. Potent preparations of this same enzyme protect mice against infection with virulent Type III Pneumococcus. The protective action is type-specific. The protective activity of the specific enzyme is destroyed by heat (70 degrees C. for 10 minutes). The enzyme remains in an effective concentration 24 to 48 hours after its injection into normal mice. The enzyme has been found to exert a favorable influence on the outcome of an infection already established at the time of treatment. A definite relationship has been found to exist between the activity of the enzyme in vitro and its protective power in the animal body. The mechanism of the protective action is discussed with special reference to the relation between the decapsulation of the bacteria by the enzyme and the phagocytic response of the host.
细菌酶能使 III 型肺炎球菌荚膜多糖在体外分解，也能破坏生长在培养基中和动物体内的生物的荚膜。这种同样的酶的有效制剂能保护小鼠免受 III 型肺炎球菌强毒的感染。保护作用具有型的特异性。特异酶的保护活性可被热（70℃10 分钟）所破坏。酶在注入正常小鼠后 24 至 48 小时仍保持有效浓度。已发现该酶对治疗时已存在的感染的转归有有利的影响。在体外酶的活力与其在动物体内的保护力之间已发现存在着明确的关系。特别参照酶对细菌的去荚膜作用与宿主的吞噬反应之间的关系讨论了保护作用的机理。
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