特定酶对 III 型肺炎球菌致兔皮肤感染的作用。
THE ACTION OF A SPECIFIC ENZYME UPON THE DERMAL INFECTION OF RABBITS WITH TYPE III PNEUMOCOCCUS.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1932 Feb 29;55(3):393-404. doi: 10.1084/jem.55.3.393.
Abstract
The action of the enzyme which specifically decomposes the capsular polysaccharide of Type III Pneumococcus has been tested in Type III pneumococcus dermal infections in rabbits. When injected in sufficient amounts, this enzyme is capable of bringing about a favorable and early termination of the experimental disease which ordinarily is fatal in nearly all instances. The results of the present study yield further evidence that the capsular substance is of great importance in pneumococcus infection, since, in so far as known, the only action of which the specific enzyme is capable is that of decomposing the capsular polysaccharide.
摘要
该酶特异性分解 III 型肺炎球菌荚膜多糖的作用已在 III 型肺炎球菌皮肤感染的兔模型中进行了测试。当注射足够量时，该酶能够使实验性疾病（通常在几乎所有情况下都是致命的）得到有利且早期的终止。本研究的结果进一步证明了荚膜物质在肺炎球菌感染中的重要性，因为据目前所知，该特异性酶唯一能够发挥作用的是分解荚膜多糖。
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