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化脓性链球菌致猩红热菌株的蛋白质组分。

PROTEIN FRACTIONS OF A SCARLATINAL STRAIN OF STREPTOCOCCUS HEMOLYTICUS.

机构信息

Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York.

出版信息

J Exp Med. 1931 Sep 30;54(4):515-31. doi: 10.1084/jem.54.4.515.

DOI:10.1084/jem.54.4.515
PMID:19869937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2132017/
Abstract
  1. A tentative method is described for extracting a labile nucleo-protein from scarlatinal Streptococcus hemolyticus. 2. The product differs chemically and serologically from the fractions prepared by subsequent alkaline extraction of the cell residues, and from protein obtained by the classical method for extraction of bacterial "nucleoproteins." 3. The new nucleoprotein is sensitive to very weak alkalies and readily loses nucleic acid under these conditions. The protein degradation products resemble the alkaline-extracted protein fractions of the cell residues. 4. The bearing of the properties of the new nucleoprotein on the chemistry of nucleoproteins in general is discussed, also the possible relation of the fractions obtained to the analysis of streptococcus antigens made by Lancefield.
摘要

  1. 本文介绍了从猩红热乙型溶血性链球菌中提取不稳定核蛋白的试验方法。

  2. 该产物在化学性质和血清学性质上与随后用碱性提取细胞残渣所制备的各部分以及用经典方法提取细菌“核蛋白”所获得的蛋白质均不相同。

  3. 新核蛋白对很弱的硷非常敏感，在这些条件下核酸极易丢失。蛋白降解产物类似于细胞残渣的碱性提取蛋白部分。

  4. 本文讨论了新核蛋白的性质对一般核蛋白化学的意义，以及所获得的各部分与 Lancefield 进行链球菌抗原分析的可能关系。

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PROTEIN FRACTIONS OF A SCARLATINAL STRAIN OF STREPTOCOCCUS HEMOLYTICUS.化脓性链球菌致猩红热菌株的蛋白质组分。
J Exp Med. 1931 Sep 30;54(4):515-31. doi: 10.1084/jem.54.4.515.
2
STUDIES ON THE BIOLOGY OF STREPTOCOCCUS : VI. BIOLOGY OF HEMOLYTIC STREPTOCOCCUS: ANTIGENIC RELATIONSHIPS BETWEEN STRAINS OF THE SCARLATINAL AND ERYSIPELAS GROUPS.链球菌生物学研究 VI：溶血性链球菌的生物学：猩红热和丹毒组菌株的抗原关系。
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A STUDY ON BACTERIAL PROTEINS WITH SPECIAL CONSIDERATION OF GONOCOCCUS AND MENINGOCOCCUS.关于细菌蛋白的研究，特别考虑到淋球菌和脑膜炎球菌。
J Exp Med. 1934 Jan 1;59(1):63-74. doi: 10.1084/jem.59.1.63.
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Acute guttate psoriasis patients have positive streptococcus hemolyticus throat cultures and elevated antistreptococcal M6 protein titers.点滴状银屑病患者咽喉部溶血性链球菌培养呈阳性，抗链球菌M6蛋白滴度升高。
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STUDIES ON THE BIOLOGY OF STREPTOCOCCUS : II. ANTIGENIC RELATIONSHIPS BETWEEN STRAINS OF STREPTOCOCCUS HAEMOLYTICUS ISOLATED FROM SCARLET FEVER.链球菌生物学研究：Ⅱ. 猩红热分离的溶血性链球菌菌株之间的抗原关系。
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STUDIES ON THE BIOLOGY OF STREPTOCOCCUS : V. ANTIGENIC RELATIONSHIPS BETWEEN STRAINS OF STREPTOCOCCUS FROM SCARLET FEVER AND ERYSIPELAS.链球菌生物学研究：V.猩红热和丹毒链球菌菌株之间的抗原关系。
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STUDIES ON THE RELATIONSHIP OF STREPTOCOCCUS HEMOLYTICUS TO THE RHEUMATIC PROCESS : III. OBSERVATIONS ON THE IMMUNOLOGICAL RESPONSES OF RHEUMATIC SUBJECTS TO HEMOLYTIC STREPTOCOCCUS.溶血性链球菌与风湿过程的关系的研究：III.风湿患者对溶血性链球菌免疫反应的观察。
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THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HAEMOLYTICUS : II. CHEMICAL AND IMMUNOLOGICAL PROPERTIES OF THE PROTEIN FRACTIONS.溶血性链球菌抗原复合物：II. 蛋白质组分的化学和免疫学性质。
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J Biophys Biochem Cytol. 1957 Jul 25;3(4):525-44. doi: 10.1083/jcb.3.4.525.

引用本文的文献

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J Exp Med. 1948 Jan 1;87(1):41-56. doi: 10.1084/jem.87.1.41.
2
STUDIES ON MENINGOCOCCAL INFECTION : XII. IMMUNOCHEMICAL STUDIES ON MENINGOCOCCUS TYPE II.关于脑膜炎球菌感染的研究：十二、脑膜炎球菌 II 型的免疫化学研究。
J Exp Med. 1942 Apr 1;75(4):437-52. doi: 10.1084/jem.75.4.437.
3
CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : VI. THE AGGLUTININ CONTENT OF ANTISERA TO HEMOLYTIC STREPTOCOCCI.细菌凝集的化学研究：六、抗溶血链球菌抗血清的凝集素含量。
J Exp Med. 1941 Jul 31;74(2):105-14. doi: 10.1084/jem.74.2.105.
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J Exp Med. 1940 Mar 31;71(4):521-37. doi: 10.1084/jem.71.4.521.
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J Exp Med. 1940 Feb 29;71(3):373-89. doi: 10.1084/jem.71.3.373.
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J Exp Med. 1939 Feb 28;69(3):425-45. doi: 10.1084/jem.69.3.425.
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J Exp Med. 1932 Oct 31;56(5):651-76. doi: 10.1084/jem.56.5.651.

本文引用的文献

1
Bio-Chemical Studies on the Bacillus Tuberculosis.结核杆菌的生物化学研究
J Med Res. 1901 Jul;6(1):135-44.
2
THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HAEMOLYTICUS : IV. ANAPHYLAXIS WITH TWO NON-TYPE-SPECIFIC FRACTIONS.溶血链球菌抗原复合物：IV. 两种非特异性片段的过敏反应。
J Exp Med. 1928 May 31;47(6):843-55. doi: 10.1084/jem.47.6.843.
3
CLASSIFICATION OF THE HEMOLYTTC STREPTOCOCCI BY THE PRECIPITIN REACTION.溶血链球菌的沉淀反应分类。
J Exp Med. 1924 Sep 30;40(4):445-52. doi: 10.1084/jem.40.4.445.
4
THE PEPTASE, LIPASE, AND INVERTASE OF HEMOLYTIC STREPTOCOCCUS.溶血链球菌的肽酶、脂肪酶和转化酶。
J Exp Med. 1922 May 31;35(6):823-46. doi: 10.1084/jem.35.6.823.