Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1934 Jul 31;60(2):211-38. doi: 10.1084/jem.60.2.211.
Monkeys that have recovered from psittacosis pneumonia have an increased resistance to infection with the virus and possess neutralizing antibodies in their sera. Large amounts of active psittacosis virus can be introduced intravenously and intramuscularly into monkeys without the production of a serious infection such as pneumonia. Relatively small amounts of virus introduced intratracheally into monkeys usually lead to psittacosis pneumonia. Monkeys vaccinated intramuscularly with unattenuated psittacosis virus have an increased resistance to the active agent and possess neutralizing antibodies in their sera. The intramuscular introduction of active psittacosis virus in moderate amounts into human beings is relatively harmless, and repeated inoculations lead to the appearance of neutralizing antibodies in the sera of vaccinated individuals.
从鹦鹉热肺炎中康复的猴子对感染该病毒具有更强的抵抗力,并在其血清中具有中和抗体。大量活性鹦鹉热病毒可通过静脉内和肌肉内途径引入猴子体内,而不会产生严重感染,如肺炎。相对少量的病毒通过气管内途径引入猴子体内通常会导致鹦鹉热肺炎。用未减毒的鹦鹉热病毒肌肉内接种的猴子对活性剂具有更强的抵抗力,并在其血清中具有中和抗体。将适量的活性鹦鹉热病毒经肌肉内引入人体相对无害,并且重复接种会导致接种个体血清中出现中和抗体。