结核分枝杆菌的菌落形态：I. 从痰以外的来源新近分离的菌株中存在光滑菌落。
THE COLONY MORPHOLOGY OF TUBERCLE BACILLI : I. THE PRESENCE OF SMOOTH COLONIES IN STRAINS RECENTLY ISOLATED FROM SOURCES OTHER THAN SPUTUM.
机构信息
Laboratories of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1935 Feb 28;61(3):395-410. doi: 10.1084/jem.61.3.395.
Abstract
- Smooth, round, shiny, non-granular, and non-spreading colonies have been observed in cultures of virulent tubercle bacilli freshly isolated from eight human sources other than sputum. The classification of six of these strains as of human type was established by inoculation into rabbits and guinea pigs. 2. The 3 per cent NaOH or 6 per cent H(2)SO(4) frequently used in the isolation of tubercle bacilli are definitely unfavorable to the development of smooth colonies. 3. It was observed that smooth colonies are produced in greater number when the pH of the medium (Corper's egg yolk-glycerine) is adjusted to a point near to but slightly on the acid side of neutral.
摘要
从除痰以外的 8 个人源中新鲜分离出的毒力结核分枝杆菌的培养物中，观察到光滑、圆形、有光泽、无颗粒且无扩散的菌落。其中 6 株的分类为人类型，通过接种到兔子和豚鼠中建立。
分离结核分枝杆菌时常用的 3%NaOH 或 6%H₂SO₄ 肯定不利于光滑菌落的生长。
观察到，当培养基（考珀氏卵黄甘油）的 pH 值调整到接近但略偏酸性时，会产生更多数量的光滑菌落。
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