结核兔的过敏反应和抗体形成。
HYPERSENSITIVENESS AND ANTIBODY FORMATION IN TUBERCULOUS RABBITS.
机构信息
Department of Pathology, Cornell University Medical College, New York.
出版信息
J Exp Med. 1936 Sep 30;64(4):573-82. doi: 10.1084/jem.64.4.573.
Abstract
- Rabbits infected with bovine tubercle bacilli develop hyper-sensitiveness to an intracutaneous injection of tuberculin. This sensitiveness appears from the 2nd to the 6th week after infection and increases rapidly thereafter. Tests, as a rule, show fluctuation in the intensity of the sensitization. Sensitization is followed by an interval of several weeks preceding death during which the animals fail to react. 2. Rabbits infected with bovine tubercle bacilli form antibodies that fix complement in the presence of tubercle bacilli. The antibodies appear after 2 weeks, increase during 6 to 10 weeks, and persist until the animals die. 3. In the later period of infection the skin fails to react to tuberculin at a time when the serum contains complement fixing antibodies.
摘要
感染牛型结核杆菌的兔子对结核菌素皮内注射产生超敏反应。这种敏感性在感染后第 2 周到第 6 周出现，并迅速增加。试验结果通常显示出致敏强度的波动。致敏后，在死亡前会有几周的间隔期，在此期间动物不再反应。
感染牛型结核杆菌的兔子会形成在结核杆菌存在下固定补体的抗体。这些抗体在感染后第 2 周出现，在第 6 周到第 10 周增加，并持续到动物死亡。
在感染后期，当血清中含有补体固定抗体时，皮肤对结核菌素不再反应。
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