Department of Pathology, State University of Iowa College of Medicine, Iowa City.
J Exp Med. 1938 May 31;67(6):911-20. doi: 10.1084/jem.67.6.911.
In biliary fistula dogs the plasma prothrombin falls eventually to low levels and bleeding commonly occurs. Faulty absorption of vitamin K from the intestine in these animals is an important causative factor. Feeding bile permits absorption of the traces of this vitamin normally present in mixed diets, and as a result a slow rise in prothrombin level is observed. If a standard diet is supplemented with large amounts of vitamin K concentrate the prothrombin rise is rapid, provided bile or bile salt is supplied to aid in the absorption. Variations in the rate of prothrombin depletion in biliary fistula dogs kept on constant diet indicate the existence of additional factors which require further study. Our experience indicates that vitamin A and vitamin D supplements do not correct the prothrombin deficiency in biliary fistula animals.
在胆瘘狗中，血浆凝血酶原最终降至低水平，并且经常发生出血。这些动物肠道对维生素 K 的吸收不良是一个重要的致病因素。胆汁的摄入允许通常存在于混合饮食中的这种维生素的痕量吸收，因此观察到凝血酶原水平的缓慢升高。如果标准饮食中补充大量维生素 K 浓缩物，只要提供胆汁或胆盐以帮助吸收，凝血酶原的升高就会很快。在接受恒定饮食的胆瘘狗中，凝血酶原耗竭率的变化表明存在需要进一步研究的其他因素。我们的经验表明，维生素 A 和维生素 D 补充剂不能纠正胆瘘动物的凝血酶原缺乏症。
