Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1940 Jan 1;71(1):43-53. doi: 10.1084/jem.71.1.43.
The soluble antigen of lymphocytic choriomeningitis which is readily separable from the virus is a relatively stable substance and appears to be of a protein nature. A specific precipitin reaction can be demonstrated when immune serum is added to solutions of antigen which have been freed of certain serologically inactive substances. The complement-fixation and precipitation reactions which occur in the presence of immune serum and non-infectious extracts of splenic tissue obtained from guinea pigs moribund with lymphocytic choriomeningitis seem to be manifestations of union of the same soluble antigen and its antibody. On the other hand, the antisoluble substance antibodies and neutralizing substances appear to be different entities.
淋巴细胞性脉络丛脑膜炎的可溶性抗原易于与病毒分离，是一种相对稳定的物质，似乎具有蛋白质性质。当免疫血清加入已除去某些血清学上无活性物质的抗原溶液中时，可以证明存在特异性沉淀反应。在免疫血清和来自患有淋巴细胞性脉络丛脑膜炎濒死的豚鼠的脾脏组织的非感染性提取物的存在下发生的补体固定和沉淀反应似乎是相同可溶性抗原与其抗体结合的表现。另一方面，抗可溶性物质抗体和中和物质似乎是不同的实体。
