豚鼠对淋巴细胞性脉络丛脑膜炎病毒的中和抗体反应。
Neutralizing antibody response of guinea pigs to lymphocytic choriomeningitis virus.
作者信息
Webster J M, Kirk B E
出版信息
Infect Immun. 1974 Sep;10(3):516-9. doi: 10.1128/iai.10.3.516-519.1974.
Abstract
A 24-h neutralization test that is based on fluorescent cell counting was used for the detection and quantitative determination of serum-neutralizing antibody against lymphocytic choriomeningitis virus. The earliest manifestation of serum-neutralizing antibody in guinea pigs was shown to occur within 1 week after inoculation with lymphocytic choriomeningitis virus. Within 11 weeks, serum-neutralizing antibody increased from 20- to 300-fold. Neutralizing end points of serum samples, obtained from 3 through 11 weeks, were enhanced as much as sevenfold by complement. Anti-guinea pig immunoglobulin G or anti-whole guinea pig serum potentiated the neutralizing activity of serum as much as 20- and 40-fold, respectively.
摘要
基于荧光细胞计数的24小时中和试验用于检测和定量测定抗淋巴细胞性脉络丛脑膜炎病毒的血清中和抗体。结果显示，豚鼠血清中和抗体的最早表现出现在接种淋巴细胞性脉络丛脑膜炎病毒后1周内。在11周内，血清中和抗体增加了20至300倍。从第3周到第11周获得的血清样本的中和终点通过补体增强了多达7倍。抗豚鼠免疫球蛋白G或抗全豚鼠血清分别使血清的中和活性增强了20倍和40倍。
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