动物和细菌来源的物质对磺胺类药物抑菌作用的抑制。
THE INHIBITION OF THE BACTERIOSTATIC ACTION OF SULFONAMIDE DRUGS BY SUBSTANCES OF ANIMAL AND BACTERIAL ORIGIN.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1940 Aug 31;72(3):217-32. doi: 10.1084/jem.72.3.217.
Sulfonamide inhibitor has been demonstrated in extracts of fresh normal muscle, pancreas, and spleen of certain animals. When autolysis of tissues takes place the amount of inhibitor is greatly increased. Fresh liver from beef, rabbit, and guinea pig is free of active inhibitor, although inhibitor is demonstrable in autolysates of this tissue. Fresh rabbit kidney is likewise free of active inhibitor. Following acid hydrolysis extracts of fresh rabbit liver and kidney cause sulfonamide inhibition. Normal human urine contains little or no active inhibitor. However, upon acid hydrolysis, inhibitor is uniformly present. Sulfonamide inhibitor is present in some, but not all, sterile serous effusions occurring during certain diseases. Inhibitor was found uniformly in pus. None was found in blood serum. In certain species of bacteria the inhibitor is found in the cells only and is not demonstrable in the culture medium, whereas in other species, the inhibitor is found in the culture supernatant, and the cells themselves are relatively free. The development of sulfapyridine fastness in a strain of Pneumococcus Type I is accompanied by a greatly increased production of sulfonamide inhibitor.
磺胺类抑制剂已在某些动物的新鲜正常肌肉、胰腺和脾脏提取物中得到证实。当组织自溶时，抑制剂的含量会大大增加。来自牛肉、兔子和豚鼠的新鲜肝脏不含活性抑制剂，尽管在该组织的自溶物中可以检测到抑制剂。新鲜的兔子肾脏也不含活性抑制剂。新鲜兔肝和肾的酸水解提取物可引起磺胺类抑制。正常人尿中含有的活性抑制剂很少或没有。然而，经过酸水解后，抑制剂普遍存在。磺胺类抑制剂存在于某些无菌浆膜渗出液中，但并非所有渗出液中都存在。在某些细菌中，抑制剂仅存在于细胞中，在培养基中无法检测到，而在其他细菌中，抑制剂存在于培养液上清液中，细胞本身相对自由。肺炎球菌 I 型中磺胺吡啶耐药性的发展伴随着磺胺类抑制剂产量的大幅增加。
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