从分泌型胃液中分离出 O 特异性物质和非分泌型胃液中的碳水化合物样物质。

THE ISOLATION OF AN O SPECIFIC SUBSTANCE FROM GASTRIC JUICE OF SECRETORS AND CARBOHYDRATE-LIKE SUBSTANCES FROM GASTRIC JUICE OF NON-SECRETORS.

Laboratories of The Buffalo General Hospital, and the Department of Pathology and Bacteriology, University of Buffalo School of Medicine, Buffalo.

J Exp Med. 1941 Apr 30;73(5):655-67. doi: 10.1084/jem.73.5.655.

Abstract

The isolation of a group specific O substance from the gastric juice of human beings belonging to group O is described. Absorbed normal beef serum constitutes the anti-O reagent. 2. The O specific substance inhibits the agglutination of human red blood cells belonging to group O. The agglutination of A cells by the isoagglutinin anti-A, or B cells by the isoagglutinin anti-B, is not influenced by the O substance. 3. The A and B specific substances isolated from human gastric juices inhibit the agglutination of O cells by absorbed normal beef serum, frequently to about the same extent as does the O substance itself. 4. The carbohydrate fraction isolated from the gastric juice of non-secretors belonging to group B does not inhibit the agglutination of human red blood cells of group B by the isoagglutinin anti-B nor the agglutination of O cells by the anti-O reagent. The significance of these findings for the conception of the nature of the blood groups and their inheritance is discussed.

摘要

从属于 O 型血人群的胃液中分离出一种特异性 O 物质。吸收的正常牛血清构成抗 O 试剂。
O 特异性物质抑制属于 O 型血的人类红细胞的凝集。同种凝集素抗 A 对 A 细胞的凝集，或同种凝集素抗 B 对 B 细胞的凝集，不受 O 物质的影响。
从人类胃液中分离出的 A 和 B 特异性物质抑制吸收的正常牛血清对 O 细胞的凝集，通常与 O 物质本身的抑制程度相同。
从属于 B 型非分泌者的胃液中分离出的碳水化合物部分既不抑制同种凝集素抗 B 对 B 型人类红细胞的凝集，也不抑制抗 O 试剂对 O 细胞的凝集。这些发现对血型的本质及其遗传的概念具有重要意义，讨论了这些发现的意义。