皮肤致敏研究：I. 同源皮肤抗原和葡萄球菌毒素协同作用产生皮肤抗体。
STUDIES IN SENSITIZATION TO SKIN : I. THE PRODUCTION OF ANTIBODIES TO SKIN BY MEANS OF THE SYNERGISTIC ACTION OF HOMOLOGOUS SKIN ANTIGEN AND STAPHYLOCOCCUS TOXIN.
机构信息
Departments of Dermatology and Physiological Chemistry of the University of Illinois College of Medicine, Chicago.
出版信息
J Exp Med. 1943 Jul 1;78(1):59-65. doi: 10.1084/jem.78.1.59.
Abstract
- Techniques for the preparation of skin antigen suitable for intramuscular injection in rabbits, and of skin antigens (autolysate) for serological experiments are described. 2. A method was evolved which produced a soluble skin antigen (autolysate) suitable for performing precipitin tests. 3. Injection of the rabbit skin antigen and of staphylococcus toxin in rabbits resulted in the formation of antibodies (precipitins) to homologous skin. 4. When homologous skin alone was injected into rabbits, the antibody formation was questionable, or at most, slight. 5. The injection of staphylococcus toxin alone resulted in antibody formation, this antibody being specific for the toxin and not reacting with broth. 6. By utilization of the synergistic action of staphylococcus toxin and of homologous skin antigen, it has been possible for the first time to produce specific antiskin antibodies in experimental animals.
摘要
描述了适用于家兔肌肉内注射的皮肤抗原和用于血清学实验的皮肤抗原（自溶物）的制备技术。
开发了一种产生可溶性皮肤抗原（自溶物）的方法，适用于进行沉淀试验。
向家兔注射兔皮肤抗原和葡萄球菌毒素，导致形成针对同源皮肤的抗体（沉淀素）。
仅注射同源皮肤时，抗体形成是可疑的，或者最多是轻微的。
单独注射葡萄球菌毒素会导致抗体形成，这种抗体是针对毒素的，与肉汤不反应。
通过葡萄球菌毒素和同源皮肤抗原的协同作用，首次有可能在实验动物中产生特异性抗皮肤抗体。
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