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1
STUDIES IN SENSITIZATION TO SKIN : I. THE PRODUCTION OF ANTIBODIES TO SKIN BY MEANS OF THE SYNERGISTIC ACTION OF HOMOLOGOUS SKIN ANTIGEN AND STAPHYLOCOCCUS TOXIN.皮肤致敏研究：I. 同源皮肤抗原和葡萄球菌毒素协同作用产生皮肤抗体。
J Exp Med. 1943 Jul 1;78(1):59-65. doi: 10.1084/jem.78.1.59.
2
[Immunological study of the occurrence of staphylococci with skin antigens in various experimental animals].[不同实验动物中葡萄球菌与皮肤抗原出现情况的免疫学研究]
Zh Mikrobiol Epidemiol Immunobiol. 1975 Jul(7):59-64.
3
STUDIES ON THE TUBERCULIN REACTION AND ON SPECIFIC HYPERSENSITIVENESS IN BACTERIAL INFECTION.关于结核菌素反应和细菌性感染特异性过敏的研究。
J Exp Med. 1921 Oct 31;34(5):495-524. doi: 10.1084/jem.34.5.495.
4
PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: FORMATION OF REACTING FACTORS IN VIVO.局部皮肤对细菌滤液的反应现象：体内反应因子的形成。
J Exp Med. 1932 Oct 31;56(5):687-703. doi: 10.1084/jem.56.5.687.
5
Studies on the antibodies in rabbit antisera responsible for sensitization of human skin. I. The role of impurities in crystalline egg albumin in stimulating the production of skin-sensitizing antibody.关于兔抗血清中引起人皮肤致敏的抗体的研究。I. 结晶卵清蛋白中的杂质在刺激皮肤致敏抗体产生中的作用。
J Exp Med. 1953 Jun;97(6):821-44. doi: 10.1084/jem.97.6.821.
6
Isolation and properties of a surface antigen of Staphylococcus aureus.金黄色葡萄球菌一种表面抗原的分离与特性
J Exp Med. 1962 Feb 1;115(2):295-311. doi: 10.1084/jem.115.2.295.
7
Precipitating antibodies against Staphylococcus aureus in experimental rabbit osteomyelitis, investigated by means of quantitative immunoelectrophoretic methods.通过定量免疫电泳方法研究实验性兔骨髓炎中抗金黄色葡萄球菌沉淀抗体。
Acta Pathol Microbiol Immunol Scand B. 1982 Jun;90(3):211-6. doi: 10.1111/j.1699-0463.1982.tb00107.x.
8
A comparison of human antisera to purified diphtheria toxoid with antisera to other purified antigens by quantitative precipitin and gel diffusion techniques.通过定量沉淀和凝胶扩散技术，将人抗纯化白喉类毒素血清与抗其他纯化抗原的血清进行比较。
J Exp Med. 1958 Oct 1;108(4):453-74. doi: 10.1084/jem.108.4.453.
9
Immunopathology of the lens. II. Humoral and cellular immune responses to homologous lens antigens and their roles in ocular inflammation.晶状体的免疫病理学。II. 对同源晶状体抗原的体液免疫和细胞免疫反应及其在眼部炎症中的作用。
Br J Ophthalmol. 1977 Apr;61(4):285-96. doi: 10.1136/bjo.61.4.285.
10
The role of non-precipitating antibodies in the passive sensitization of human skin by rabbit anti-ovalbumin.非沉淀抗体在兔抗卵白蛋白对人皮肤的被动致敏中的作用。
J Exp Med. 1950 Sep;92(3):191-200. doi: 10.1084/jem.92.3.191.

引用本文的文献

1
The Synergic Activity of Staphylococcus Toxin.葡萄球菌毒素的协同活性
Yale J Biol Med. 1944 Dec;17(2):359-82.
2
HETEROGENETIC ANTIBODIES IN ACUTE HEPATITIS.急性肝炎中的异源抗体。
J Exp Med. 1944 May 1;79(5):539-57. doi: 10.1084/jem.79.5.539.
3
[On scatter phenomena in the course of eczema].[关于湿疹病程中的散射现象]
Arch Klin Exp Dermatol. 1960;211:298-303.
4
[CONTRIBUTIONS TO THE STUDY OF AUTOIMMUNIZATION AND THE ROLE OF THIS PHENOMENON IN THE PATHOGENESIS OF SOME PATHOLOGICAL SKIN MANIFESTATIONS. I. EXPERIMENTAL RESEARCH IN CONNECTION WITH THE DEMONSTRATION OF THE DEVELOPMENT OF SOME ORGAN ANTIBODIES].[对自身免疫研究的贡献以及这一现象在某些病理性皮肤表现发病机制中的作用。一、与某些器官抗体产生相关的实验研究]
Arch Klin Exp Dermatol. 1964 Oct 20;220:492-516.
5
The problem of auto-antibodies.自身抗体问题。
Klin Wochenschr. 1954 Sep 1;32(33-34):770-7. doi: 10.1007/BF01477603.
6
[Experimental studies on tuberculin allergic reaction of the central nervous system].[中枢神经系统结核菌素过敏反应的实验研究]
Z Hyg Infektionskr. 1953;137(2):130-44.
7
Humoral factors in the pathogenesis of the human hypertension.人类高血压发病机制中的体液因素。
Arch Kreislaufforsch. 1952 Sep;18(7-10):249-300.
8
[The significance of animate pathogens for the formation of auto-antibodies].[有生命病原体在自身抗体形成中的意义]
Klin Wochenschr. 1952 Mar 1;30(9-10):193-6. doi: 10.1007/BF01500849.
9
The bacterial induction of homograft sensitivity. II. Effects of sensitization with staphylococci and other microoorganisms.同种异体移植敏感性的细菌诱导。II. 葡萄球菌及其他微生物致敏的影响。
J Exp Med. 1965 Oct 1;122(4):733-44. doi: 10.1084/jem.122.4.733.

本文引用的文献

1
EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : I. PREPARATION AND IMMUNOLOGICAL STUDIES OF NEPHROTOXIN.抗肾血清注射致大鼠实验性肾炎：I. 肾毒素的制备和免疫学研究。
J Exp Med. 1936 Nov 30;64(6):921-42. doi: 10.1084/jem.64.6.921.
2
STUDIES IN SYNERGY : THE SYNERGIC ACTION OF STAPHYLOTOXIN AND BEEF LENS EXTRACT IN RABBITS.协同作用研究：金葡菌肠毒素与牛晶状体提取物在兔体内的协同作用。
J Exp Med. 1936 Apr 30;63(5):703-24. doi: 10.1084/jem.63.5.703.
3
ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS.猴实验性引起的伴髓鞘破坏的脑脊髓炎。
J Exp Med. 1935 Apr 30;61(5):689-702. doi: 10.1084/jem.61.5.689.
4
THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN.家兔同种脑的乳化液和提取物注射后的抗体反应。
J Exp Med. 1934 Oct 31;60(5):559-74. doi: 10.1084/jem.60.5.559.

皮肤致敏研究：I. 同源皮肤抗原和葡萄球菌毒素协同作用产生皮肤抗体。

STUDIES IN SENSITIZATION TO SKIN : I. THE PRODUCTION OF ANTIBODIES TO SKIN BY MEANS OF THE SYNERGISTIC ACTION OF HOMOLOGOUS SKIN ANTIGEN AND STAPHYLOCOCCUS TOXIN.

机构信息

Departments of Dermatology and Physiological Chemistry of the University of Illinois College of Medicine, Chicago.

出版信息

J Exp Med. 1943 Jul 1;78(1):59-65. doi: 10.1084/jem.78.1.59.

DOI:10.1084/jem.78.1.59
PMID:19871309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2135363/
Abstract
  1. Techniques for the preparation of skin antigen suitable for intramuscular injection in rabbits, and of skin antigens (autolysate) for serological experiments are described. 2. A method was evolved which produced a soluble skin antigen (autolysate) suitable for performing precipitin tests. 3. Injection of the rabbit skin antigen and of staphylococcus toxin in rabbits resulted in the formation of antibodies (precipitins) to homologous skin. 4. When homologous skin alone was injected into rabbits, the antibody formation was questionable, or at most, slight. 5. The injection of staphylococcus toxin alone resulted in antibody formation, this antibody being specific for the toxin and not reacting with broth. 6. By utilization of the synergistic action of staphylococcus toxin and of homologous skin antigen, it has been possible for the first time to produce specific antiskin antibodies in experimental animals.
摘要

  1. 描述了适用于家兔肌肉内注射的皮肤抗原和用于血清学实验的皮肤抗原（自溶物）的制备技术。

  2. 开发了一种产生可溶性皮肤抗原（自溶物）的方法，适用于进行沉淀试验。

  3. 向家兔注射兔皮肤抗原和葡萄球菌毒素，导致形成针对同源皮肤的抗体（沉淀素）。

  4. 仅注射同源皮肤时，抗体形成是可疑的，或者最多是轻微的。

  5. 单独注射葡萄球菌毒素会导致抗体形成，这种抗体是针对毒素的，与肉汤不反应。

  6. 通过葡萄球菌毒素和同源皮肤抗原的协同作用，首次有可能在实验动物中产生特异性抗皮肤抗体。