Rapaport F T, Chase R M
J Exp Med. 1965 Oct 1;122(4):733-44. doi: 10.1084/jem.122.4.733.
Heat-killed strains of Staphylococcus aureus and Staphylococcus albus can induce in guinea pigs a state of altered reactivity to skin homografts which is indistinguishable from that which results from sensitization with homologous tissues or Group A streptococci. Challenge of suitably prepared recipients with first-set skin homografts obtained from unrelated randomly selected donors elicits white graft reactions or accelerated rejection of such grafts. Other bacteria tested included Lancefield streptococcal groups B, C, D, E, G, H, L, and O, pneumococcus Types II, III, XIV and a rough strain, Corynebacterium xerosis, Bacillus subtilis, Escherichia coli, Aerobacter aerogenes, Salmonella typhimurium, Proteus vulgaris, Neisseria catarrhalis, Haemophilus influenzae, and two human virulent strains of Mycobacterium tuberculosis. None of these microorganisms was active in the induction of homograft sensitivity in the guinea pig. Pretreatment of recipients with Gram-negative bacterial suspensions was associated with a slight increase in the mean survival time of first-set skin homografts. Results of this study suggest the presence in staphylococci, as well as in Group A streptococci, of antigens related in their biologic effects to tissue transplantation antigens.
金黄色葡萄球菌和白色葡萄球菌的热灭活菌株可在豚鼠中诱导出对皮肤同种异体移植的反应性改变状态，这种状态与用同源组织或A组链球菌致敏所导致的状态无法区分。用从随机选择的无关供体获得的初次皮肤同种异体移植对适当准备的受体进行攻击，会引发白色移植反应或加速此类移植的排斥。测试的其他细菌包括兰斯菲尔德B、C、D、E、G、H、L和O组链球菌、II型、III型、XIV型肺炎球菌和一种粗糙菌株、干燥棒状杆菌、枯草芽孢杆菌、大肠杆菌、产气气杆菌、鼠伤寒沙门氏菌、普通变形杆菌、卡他莫拉菌、流感嗜血杆菌以及两株人结核分枝杆菌强毒株。这些微生物均未在豚鼠中诱导同种异体移植敏感性。用革兰氏阴性菌悬液对受体进行预处理与初次皮肤同种异体移植的平均存活时间略有增加有关。本研究结果表明，葡萄球菌以及A组链球菌中存在在生物学效应上与组织移植抗原相关的抗原。
