Research Laboratory of the California State Department of Public Health, Berkeley.
J Exp Med. 1945 Oct 31;82(5):329-42. doi: 10.1084/jem.82.5.329.
Significant increases in neutralizing antibodies were demonstrated in 42 of a total of 69 persons with a clinical diagnosis of primary atypical pneumonia. Detailed titrations of virus-neutralizing antibodies in a representative group of 28 patients are presented. Increases of four- to 64-fold were demonstrated. Acute-phase titers were 4 or less in 83 per cent and convalescent titers were 16 or over in 86 per cent of these cases. Only about half of the number of patients having increases in neutralizing antibodies also developed cold agglutinins and agglutinins for the indifferent streptococcus No. 344. Patients from the Eastern United States as well as those from the Pacific Coast were shown to develop virus-neutralizing antibodies. Patients with pneumococcal pneumonia and pneumonias caused by influenza virus type A or viruses of the psittacosis group did not have significant increases in neutralizing antibodies for the virus of atypical pneumonia. Cold agglutinins appeared in 3 cases of type A influenzal pneumonia. Sera from persons with atypical pneumonia, when tested against the 3 most prevalent respiratory viruses isolated from cotton rats and hamsters, failed to neutralize these agents or showed no significant change in neutralization titer.
在总共 69 名临床诊断为原发性非典型肺炎的人中，有 42 人的中和抗体显著增加。本文呈现了对 28 名患者的代表性病毒中和抗体的详细滴定。结果显示，中和抗体增加了 4 至 64 倍。83%的急性发病时滴度为 4 或更低，86%的恢复期滴度为 16 或更高。只有约一半的具有中和抗体增加的患者也产生了冷凝集素和对 344 号不相关链球菌的凝集素。来自美国东部和太平洋沿岸的患者都产生了该非典型肺炎病毒的中和抗体。肺炎球菌性肺炎和由甲型流感病毒或鹦鹉热组病毒引起的肺炎患者的中和抗体没有显著增加。3 例 A 型流感肺炎出现冷凝集素。用棉鼠和仓鼠分离的最常见的 3 种呼吸道病毒检测非典型肺炎患者的血清，未能中和这些病原体，或中和效价没有显著变化。
