[博落回中的生物碱]

[Alkaloids from Macleaya cordata].

作者信息

Ye Fengzhi, Feng Feng, Liu Wenyuan

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(13):1683-6.

PMID:19873781

Abstract

OBJECTIVE

To study the alkaloids of Macleaya cordata.

METHOD

The alkaloids were isolated and purified by various column chromatography as well as recrystallization. Their structures were identified by physico-chemical properties and spectral analysis.

RESULT

Thirteen alkaloids were isolated and identified as 6-methoxy-dihydrosanguinarine (1), norsanguinarine (2), 6-acetonyl-dihyrochelerythrine (3), 6-acetonyl-dihyrosanguinnarine (4), sanguidimerine (5), chelidimerine (6), (+/-) -bocconarborine A (7), (+/-)-bocconarborine B (8), cryptopine (9), dihydrosanguinarine (10), dihydrochelerythrine (11), protopine (12), alpha-allocryptopine (13).

CONCLUSION

Compounds 2, 3, 5 - 9 were firstly isolated from the genus Macleaya and compound 1 was obtained from M. cordata for the first time.

摘要

目的

研究博落回中的生物碱。

方法

通过各种柱色谱法以及重结晶法对生物碱进行分离和纯化。通过物理化学性质和光谱分析确定其结构。

结果

分离并鉴定出13种生物碱，分别为6-甲氧基-二氢血根碱（1）、去甲血根碱（2）、6-丙酮基-二氢白屈菜红碱（3）、6-丙酮基-二氢血根碱（4）、血根二聚碱（5）、白屈二聚碱（6）、（±）-博落回碱A（7）、（±）-博落回碱B（8）、隐品碱（9）、二氢血根碱（10）、二氢白屈菜红碱（11）、原阿片碱（12）、α-别隐品碱（13）。