生物聚合物聚（二磷酸腺苷核糖）的天然存在。
Natural occurence of a biopolymer, poly (adenosine diphosphate ribose).
作者信息
Sakura H, Miwa M, Tanaka M, Kanai Y, Shimada T, Matsushima T, Sugimura T
出版信息
Nucleic Acids Res. 1977 Aug;4(8):2903-15. doi: 10.1093/nar/4.8.2903.
Abstract
Evidence for the natural occurrence of poly(adenosine diphosphate ribose) in vivo was obtained using a sensitive radioimmunoassay and poly(adenosine diphosphate ribose) glycohydrolase, which specifically hydrolyzes poly(adenosine diphosphate ribose). Calf thymus, liver, kidney, brain, pancreas and spleen contained poly(adenosine diphosphate ribose). Naturally occurring poly(adenosine diphosphate ribose) in calf thymus is composed of molecules of various chain lengths, like that synthesized by an in vitro system. Calf thymus was estimated to contain about 0.02 microgram/mg DNA of poly(adenosine diphosphate ribose).
摘要
利用一种灵敏的放射免疫测定法以及特异性水解聚（二磷酸腺苷核糖）的聚（二磷酸腺苷核糖）糖苷水解酶，获得了体内天然存在聚（二磷酸腺苷核糖）的证据。小牛胸腺、肝脏、肾脏、大脑、胰腺和脾脏均含有聚（二磷酸腺苷核糖）。小牛胸腺中天然存在的聚（二磷酸腺苷核糖）由各种链长的分子组成，类似于体外系统合成的聚（二磷酸腺苷核糖）。据估计，小牛胸腺中聚（二磷酸腺苷核糖）的含量约为0.02微克/毫克DNA。
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本文引用的文献
1
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J Infect Dis. 1958 Nov-Dec;103(3):239-62. doi: 10.1093/infdis/103.3.239.
2
3
Identification of poly (ADP-ribose) covalently bound to histone F1 in vivo.体内与组蛋白F1共价结合的聚（ADP-核糖）的鉴定。
Biochem Biophys Res Commun. 1973 Sep 5;54(1):297-300. doi: 10.1016/0006-291x(73)90922-4.
4
Poly ADP-ribose synthesis and DNA replication in synchronized mouse L-cells.同步化小鼠L细胞中的聚ADP核糖合成与DNA复制
Biochem Biophys Res Commun. 1973 Aug 6;53(3):960-6. doi: 10.1016/0006-291x(73)90185-x.
5
Poly(adenosine diphosphate ribose) synthesis during the cell cycle of transformed hamster lung cells.转化的仓鼠肺细胞细胞周期中聚（二磷酸腺苷核糖）的合成
Cancer Res. 1973 Jun;33(6):1306-9.
6
Studies on poly(adenosine diphosphate-ribose). XI. Purification of poly(adenosine diphosphate-ribose) on a hydroxylapatite column.聚（二磷酸腺苷核糖）的研究。XI. 在羟基磷灰石柱上纯化聚（二磷酸腺苷核糖）。
Arch Biochem Biophys. 1971 Dec;147(2):660-5. doi: 10.1016/0003-9861(71)90425-5.
7
Activity of polyadenosine diphosphoribose polymerase during the human cell cycle.人细胞周期中多聚腺苷二磷酸核糖聚合酶的活性
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8
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9
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10
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