生物聚合物聚（二磷酸腺苷核糖）的天然存在。
Natural occurence of a biopolymer, poly (adenosine diphosphate ribose).
作者信息
Sakura H, Miwa M, Tanaka M, Kanai Y, Shimada T, Matsushima T, Sugimura T
出版信息
Nucleic Acids Res. 1977 Aug;4(8):2903-15. doi: 10.1093/nar/4.8.2903.
Abstract
Evidence for the natural occurrence of poly(adenosine diphosphate ribose) in vivo was obtained using a sensitive radioimmunoassay and poly(adenosine diphosphate ribose) glycohydrolase, which specifically hydrolyzes poly(adenosine diphosphate ribose). Calf thymus, liver, kidney, brain, pancreas and spleen contained poly(adenosine diphosphate ribose). Naturally occurring poly(adenosine diphosphate ribose) in calf thymus is composed of molecules of various chain lengths, like that synthesized by an in vitro system. Calf thymus was estimated to contain about 0.02 microgram/mg DNA of poly(adenosine diphosphate ribose).
摘要
利用一种灵敏的放射免疫测定法以及特异性水解聚（二磷酸腺苷核糖）的聚（二磷酸腺苷核糖）糖苷水解酶，获得了体内天然存在聚（二磷酸腺苷核糖）的证据。小牛胸腺、肝脏、肾脏、大脑、胰腺和脾脏均含有聚（二磷酸腺苷核糖）。小牛胸腺中天然存在的聚（二磷酸腺苷核糖）由各种链长的分子组成，类似于体外系统合成的聚（二磷酸腺苷核糖）。据估计，小牛胸腺中聚（二磷酸腺苷核糖）的含量约为0.02微克/毫克DNA。
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