Chemistry Department, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Mem Inst Oswaldo Cruz. 2009 Sep;104(6):813-7. doi: 10.1590/s0074-02762009000600002.
Three Plumbago spp have been tested for mosquito larvicidal activity. The crude extracts exhibiting the highest larvicidal activity against Anopheles gambiae were hexane (LC50 = 6.4 microg/mL) and chloroform (LC50 = 6.7 microg/mL) extracts from Plumbago zeylanica Linn, chloroform (LC50 = 6.7 ug/mL) extract from Plumbago stenophylla Bull and ethyl acetate (LC50 = 4.1 microg/mL) extract from Plumbago dawei Rolfe. These LC50 values were within 95% confidence limits. 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin) 1 (LC50 = 1.9 microg/mL) and beta-sitosterol 2 were characterised from ethyl acetate extract of root bark of P. dawei, a native medicinal plant growing in Kenya, based on spectral analysis and comparisons with data in literature.
三种白花丹属植物已被测试其对蚊虫幼虫的杀虫活性。从白花丹（Plumbago zeylanica Linn）中获得的正己烷（LC50 = 6.4 微克/毫升）和氯仿（LC50 = 6.7 微克/毫升）提取物，以及从秀丽白花丹（Plumbago stenophylla Bull）中获得的氯仿（LC50 = 6.7 微克/毫升）提取物，对冈比亚按蚊（Anopheles gambiae）显示出最高的杀虫活性，而从大花白花丹（Plumbago dawei Rolfe）中获得的乙酸乙酯（LC50 = 4.1 微克/毫升）提取物。这些 LC50 值在 95%置信限内。从肯尼亚土生土长的药用植物大花白花丹的根皮乙酸乙酯提取物中，基于光谱分析和与文献数据的比较，鉴定出了 5-羟基-2-甲基-1,4-萘醌（白花丹醌）1（LC50 = 1.9 微克/毫升）和β-谷甾醇 2。
