Hayano J, Sakakibara Y, Yamada A, Yamada M, Mukai S, Fujinami T, Yokoyama K, Watanabe Y, Takata K
Third Department of Internal Medicine, Nagoya City University Medical School, Japan.
Am J Cardiol. 1991 Jan 15;67(2):199-204. doi: 10.1016/0002-9149(91)90445-q.
The correlations of 11 indexes of heart rate variability were examined with pharmacologically determined cardiac vagal tone in 15 normal subjects at supine rest. After sympathetic influences by intravenous propranolol were eliminated, RR interval variability was measured for 10 minutes under controlled respiration (0.25 Hz), and cardiac vagal tone was determined as the decrease in mean RR interval following complete vagal blockade with atropine. Time domain indexes (standard deviation, coefficient of variance and mean successive difference) correlated strongly with vagal tone (r = 0.87, 0.81 and 0.92, respectively; p less than 0.001 for all). The same was true for frequency domain indexes for the high-frequency (0.25 Hz) component calculated both by autoregressive spectrum analysis (square root of power and coefficient of component variance) and by fast Fourier transform (mean amplitude) (r = 0.91, 0.85 and 0.86, respectively; p less than 0.0001 for all). However, frequency domain indexes for the low-frequency spectral component (0.03 to 0.15 Hz) correlated less strongly (r = 0.69, 0.55 and 0.70, respectively), and the fraction of power [power/(total power greater than 0.03 Hz)] of both components showed no correlation. Principal component analysis showed that the first 6 indexes with strong correlations contained solely the first principal component closely related to vagal tone, whereas the remaining 5 indexes also contained the second component unrelated to vagal tone. These results indicate that most of the time and frequency domain analyses in use provides an accurate and common measure of cardiac vagal tone at rest.
在15名正常受试者仰卧休息时，研究了心率变异性的11个指标与药理学测定的心脏迷走神经张力之间的相关性。在通过静脉注射普萘洛尔消除交感神经影响后，在控制呼吸（0.25Hz）下测量RR间期变异性10分钟，并用阿托品完全阻断迷走神经后平均RR间期的减少来确定心脏迷走神经张力。时域指标（标准差、变异系数和平均逐差）与迷走神经张力密切相关（分别为r = 0.87、0.81和0.92；均p<0.001）。通过自回归谱分析（功率平方根和分量变异系数）和快速傅里叶变换（平均幅度）计算的高频（0.25Hz）分量的频域指标也是如此（分别为r = 0.91、0.85和0.86；均p<0.0001）。然而，低频谱分量（0.03至0.15Hz）的频域指标相关性较弱（分别为r = 0.69、0.55和0.70），且两个分量的功率分数[功率/（总功率>0.03Hz）]无相关性。主成分分析表明，相关性强的前6个指标仅包含与迷走神经张力密切相关的第一主成分，而其余5个指标还包含与迷走神经张力无关的第二成分。这些结果表明，大多数常用的时域和频域分析方法可准确且一致地测量静息时的心脏迷走神经张力。
