Post graduation Program in Pediatric Dentistry, UNESP-São Paulo State University, Araçatuba Dental School, São Paulo, Brazil.
Acta Odontol Scand. 2010 Jan;68(1):11-8. doi: 10.3109/00016350903260264.
This in situ study evaluated the remineralizing potential of pit and fissure sealants containing amorphous calcium phosphate (ACP) and/or fluoride in artificially induced carious lesions on smooth enamel surfaces.
Ten volunteers who wore acrylic palatal devices were enrolled in this 5-day double-blind study and assigned to one of the following five groups: (I) demineralized enamel slab+Fluroshield (sealant with fluoride); (II) demineralized enamel slab+Aegis (sealant with ACP); (III) demineralized enamel slab+experimental sealant with fluoride (ESF); (IV) demineralized enamel slab+experimental sealant with fluoride/ACP (ACP-F); and (V) demineralized enamel slab (control). After the experimental period, the percentage of surface microhardness recovery (%SMHR) and the integrated loss of subsurface hardness (DeltaKHN) were evaluated. The concentrations of fluoride, calcium and phosphorus in enamel were also determined.
The sealants containing ACP and/or fluoride presented a higher remineralizing capacity (%SMHR and DeltaKHN) than that of the control group. Aegis provided either more efficient or similar remineralization than the other sealants. The association between ACP and fluoride did not show a greater efficacy in the remineralization. F, Ca and P concentrations in enamel varied according to the group.
The pit and fissure sealants containing ACP were able to promote remineralization of artificially induced carious lesions on smooth enamel surfaces.
本原位研究评估了含有无定形磷酸钙（ACP）和/或氟化物的窝沟封闭剂在人工诱导的平滑釉质表面龋损中的再矿化潜力。
10 名佩戴丙烯酸腭部装置的志愿者参加了这项为期 5 天的双盲研究，并被分配到以下五个组之一：（I）脱矿釉质板+Fluroshield（含氟封闭剂）；（II）脱矿釉质板+Aegis（含 ACP 的封闭剂）；（III）脱矿釉质板+含氟实验性封闭剂（ESF）；（IV）脱矿釉质板+含氟/ACP 实验性封闭剂（ACP-F）；和（V）脱矿釉质板（对照组）。实验期结束后，评估表面显微硬度恢复率（%SMHR）和亚表面硬度综合损失（DeltaKHN）。还测定了釉质中氟、钙和磷的浓度。
含有 ACP 和/或氟化物的封闭剂比对照组具有更高的再矿化能力（%SMHR 和 DeltaKHN）。Aegis 提供的再矿化效率要么更高，要么与其他封闭剂相似。ACP 和氟化物的联合使用在再矿化方面没有表现出更大的功效。釉质中 F、Ca 和 P 的浓度根据组而变化。
含有 ACP 的窝沟封闭剂能够促进人工诱导的平滑釉质表面龋损的再矿化。
