Kagimoto T, Oda T, Nakakuma H, Kawaguchi T, Hidaka M, Horikawa K, Matsuzaki H, Takatsuki K
Dept. of 2nd Internal Medicine, Kumamoto University Medical School.
Gan To Kagaku Ryoho. 1991 Jan;18(1):63-7.
Serum deoxythymidine kinase activities (s-TK) of the patients with adult T-cell leukemia (ATL), carriers and healthy persons were measured, using a recently developed TK assay with 125I-iodo-deoxyuridine as a substrate. The mean s-TK values were 3.3 +/- 2.7 U/l (n = 21) in normal subjects (HTLV-1(-)), 4.7 +/- 5.0 U/l (n = 35) in carriers, 9.8 U/l (n = 3) in smoldering ATL and 26.7 U/l (n = 6) in chronic ATL. In the patients with acute ATL, the mean s-TK values before and after chemotherapy were 80.9 U/l (n = 2) and 11.6 U/l (n = 4), respectively. In the follow-up studies of the patients with acute ATL, the changes of s-TK levels revealed earlier than those of serum LDH levels. It is suggested that s-TK activity is more useful than LDH as a parameter of monitoring treatment in ATL.
采用最近开发的以125I-碘脱氧尿苷为底物的胸苷激酶（TK）检测方法，对成人T细胞白血病（ATL）患者、携带者和健康人的血清脱氧胸苷激酶活性（s-TK）进行了检测。正常受试者（HTLV-1(-)）的平均s-TK值为3.3±2.7 U/l（n = 21），携带者为4.7±5.0 U/l（n = 35），冒烟型ATL患者为9.8 U/l（n = 3），慢性ATL患者为26.7 U/l（n = 6）。急性ATL患者化疗前后的平均s-TK值分别为80.9 U/l（n = 2）和11.6 U/l（n = 4）。在急性ATL患者的随访研究中，s-TK水平的变化比血清LDH水平的变化出现得更早。提示s-TK活性作为ATL治疗监测指标比LDH更有用。
