Sadamori N, Ikeda S, Yamaguchi K, Mine M, Hakariya S, Kinoshita H, Hayashi K, Nakamura T, Nagataki S, Ichimaru M
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
Leuk Res. 1991;15(2-3):99-103. doi: 10.1016/0145-2126(91)90089-c.
Serum deoxythymidine kinase (TK) was measured in 15 patients with the acute type of adult T-cell leukemia (ATL), in 4 with chronic ATL, in 10 with lymphoma type ATL, in 9 with pre-ATL, in 11 with human T-cell leukemia virus type I (HTLV-I) associated with myelopathy (HAM) and in 19 HTLV-I carriers. All these patients were positive for anti-HTLV antibody. The level of TK in pretreatment serum was highest in acute ATL (15.6-1600 U/l, median 107 U/l). It was elevated in chronic ATL (5.4-55.0 U/l, median 37.6 U/l) and lymphoma ATL (6.8-316 U/l, median 16.8 U/l) but normal in pre-ATL (1.8-4.7 U/l, median 2.8 U/l), HAM (1.2-6.0 U/l, median 3.0 U/l) and HTLV-I carriers (1.1-4.6 U/l, median 2.3 U/l). Statistical examination revealed a significant difference between the levels of acute ATL and chronic ATL/lymphoma ATL. In the patients of this series, a close correlation between the level of TK and lactic dehydrogenase (LDH) was statistically present (p less than 0.01). These facts indicate that TK level is a useful indicator of the aggressiveness of ATL cells.
检测了15例急性型成人T细胞白血病（ATL）患者、4例慢性ATL患者、10例淋巴瘤型ATL患者、9例ATL前期患者、11例与脊髓病相关的I型人类T细胞白血病病毒（HTLV-I）感染者以及19例HTLV-I携带者的血清脱氧胸苷激酶（TK）。所有这些患者的抗HTLV抗体均为阳性。预处理血清中TK水平在急性ATL中最高（15.6 - 1600 U/l，中位数107 U/l）。在慢性ATL（5.4 - 55.0 U/l，中位数37.6 U/l）和淋巴瘤型ATL（6.8 - 316 U/l，中位数16.8 U/l）中升高，但在ATL前期（1.8 - 4.7 U/l，中位数2.8 U/l）、HAM（1.2 - 6.0 U/l，中位数3.0 U/l）和HTLV-I携带者（1.1 - 4.6 U/l，中位数2.3 U/l）中正常。统计学检验显示急性ATL与慢性ATL/淋巴瘤型ATL的水平之间存在显著差异。在本系列患者中，TK水平与乳酸脱氢酶（LDH）之间在统计学上存在密切相关性（p < 0.01）。这些事实表明TK水平是ATL细胞侵袭性的一个有用指标。
