Sadamori N, Yamaguchi K, Ikeda S, Hakariya S, Mine M, Itoyama T, Iwasaki H, Kinoshita H, Hayashi K, Ichimaru M
Department of Internal Medicine, Magasaki University School of Medicine.
Rinsho Ketsueki. 1990 Nov;31(11):1812-7.
Using Prolifigen TK kit "Daiichi", the serum TK level were determined in patients with adult T-cell leukemia (ATL) and its related disorders. The mean level of serum TK at diagnosis was 279.9 U/l in acute type ATL, 27.8 U/l in chronic type ATL, 59.0 U/l in lymphoma type ATL, 3.1 U/l in pre-ATL and 2.4 U/l in HTLV-I carriers. In these patients, six other kinds of tumor markers such as lactic dehydrogenase, beta 2-microglobulin, immunosuppressive acidic protein, ferritin, tissue polypeptide antigen and carcinoembryonic antigen were also examined. Among the seven tumor markers, TK level showed the most significant difference among clinical subtypes of ATL. This indicates that the TK level is one of the promising parameters indicative of aggressiveness of ATL cells.
使用第一制药的增殖素TK试剂盒，测定了成人T细胞白血病（ATL）患者及其相关疾病患者的血清TK水平。急性型ATL患者诊断时血清TK的平均水平为279.9 U/l，慢性型ATL为27.8 U/l，淋巴瘤型ATL为59.0 U/l，ATL前期为3.1 U/l，HTLV-I携带者为2.4 U/l。在这些患者中，还检测了其他六种肿瘤标志物，如乳酸脱氢酶、β2-微球蛋白、免疫抑制酸性蛋白、铁蛋白、组织多肽抗原和癌胚抗原。在这七种肿瘤标志物中，TK水平在ATL的临床亚型之间显示出最显著的差异。这表明TK水平是指示ATL细胞侵袭性的有前景的参数之一。
