Wilson C A, Royster A J, Tiedeman J S, Hatchell D L
Veterans Administration Medical Center, Durham, NC.
Arch Ophthalmol. 1991 Jan;109(1):125-34. doi: 10.1001/archopht.1991.01080010127044.
Exudative retinal detachments occur in a variety of retinal and choroidal diseases. We created serous retinal detachment in the cat eye by means of photodynamic injury produced by activation of intravascular rose bengal using filtered, focused light (550 nm). Fluorescein angiography later revealed focal retinal and choroidal vascular occlusion surrounded by a larger area of leakage through the pigment epithelium. Serous retinal detachments occurred rapidly, gradually enlarged over the next 3 days, and resolved in all eyes after 14 to 21 days. Histopathologic and ultrastructural features of early lesions included the accumulation of proteinaceous fluid in the subretinal space, pigment epithelial cell damage, and localized occlusion of retinal vessels and the choriocapillaris. Later changes consisted of limited regeneration of the retina and portions of the tapetum. In several respects, these experimental detachments resemble the serous retinal detachments associated with choroidal ischemia in humans, and may serve as a useful model in the study of choroidal microvascular hypoperfusion.
渗出性视网膜脱离发生于多种视网膜和脉络膜疾病。我们通过使用滤光、聚焦的光（550纳米）激活血管内孟加拉玫瑰红产生光动力损伤，在猫眼造成浆液性视网膜脱离。荧光素血管造影后来显示局灶性视网膜和脉络膜血管阻塞，周围有更大面积通过色素上皮的渗漏。浆液性视网膜脱离迅速发生，在接下来的3天逐渐扩大，并在14至21天后在所有眼中消退。早期病变的组织病理学和超微结构特征包括视网膜下间隙中蛋白质液体的积聚、色素上皮细胞损伤以及视网膜血管和脉络膜毛细血管的局部阻塞。后期变化包括视网膜和部分反光层的有限再生。在几个方面，这些实验性脱离类似于人类与脉络膜缺血相关的浆液性视网膜脱离，并且可作为研究脉络膜微血管灌注不足的有用模型。
