Marmor M F, Yao X Y
Department of Ophthalmology, Stanford University School of Medicine, Calif.
Arch Ophthalmol. 1994 Jun;112(6):830-8. doi: 10.1001/archopht.1994.01090180130047.
To evaluate experimentally the conditions necessary for the formation of serous detachments.
Selective injury to the retinal pigment epithelium (RPE) and choriocapillaris was produced in cats using weak laser burns and intense diffuse light, with or without photosensitization with rose bengal. The fundi were analyzed by observation, fluorescein angiography, and histologic examination.
Injuring the RPE alone did not cause detachments. Focal injury to the RPE and choriocapillaris caused moderate detachment only when an area surrounding the focal leakage site had been subjected to light damage. Diffuse injury to the RPE and choriocapillaris caused broader detachments.
Three conditions are necessary for serous detachments to form: (1) a source of fluid pressure, (2) a defect in the blood-retinal barrier (entry site), and (3) an area of impaired fluid transport beyond the site of leakage (if fluid is to accumulate over a broader area).
通过实验评估浆液性脱离形成所需的条件。
使用弱激光烧灼和强光漫射，对猫的视网膜色素上皮（RPE）和脉络膜毛细血管进行选择性损伤，同时使用或不使用孟加拉玫瑰红进行光敏化处理。通过观察、荧光素血管造影和组织学检查对眼底进行分析。
单独损伤RPE不会导致脱离。仅当局灶性渗漏部位周围区域受到光损伤时，RPE和脉络膜毛细血管的局灶性损伤才会导致中度脱离。RPE和脉络膜毛细血管的弥漫性损伤会导致更广泛的脱离。
浆液性脱离形成需要三个条件：（1）液体压力源；（2）血视网膜屏障缺陷（进入部位）；（3）渗漏部位以外液体运输受损的区域（如果液体要在更广泛的区域积聚）。
