Solidage Research Group, Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Quebec, Canada.
J Clin Epidemiol. 2010 Jun;63(6):647-54. doi: 10.1016/j.jclinepi.2009.08.007. Epub 2009 Oct 31.
To examine the relationships among seven frailty domains: nutrition, physical activity, mobility, strength, energy, cognition, and mood, using data from three studies.
Data from three studies were separately analyzed using multiple correspondence analysis (MCA). The graphical output of MCA was used to assess (1) if the presence of deficits in the frailty domains separate from the absence of deficits on the graph, (2) the dimensionality of the domains, (3) the clustering of domains within each dimension, and (4) their relationship with age, sex, and disability. Results were compared across the studies.
In two studies, presence of deficits for all domains separated from absence of deficits. In the third study, there was separation in all domains except cognition. Three main dimensions were retained in each study; however, assigned dimensionality of domains differed. The clustering of mobility with energy and/or strength was consistent across studies. Deficits were associated with older age, female sex, and disability.
Our results suggest that frailty is a multidimensional concept for which the relationships among domains differ according to the population characteristics. These domains, with the possible exception of cognition, appear to aggregate together and share a common underlying construct.
使用来自三项研究的数据，考察营养、身体活动、移动能力、力量、能量、认知和情绪这七个虚弱领域之间的关系。
使用多元对应分析（MCA）分别对来自三项研究的数据进行分析。MCA 的图形输出用于评估（1）在图形上是否存在缺陷与不存在缺陷分开，（2）领域的维度，（3）每个维度内领域的聚类，以及（4）它们与年龄、性别和残疾的关系。结果在研究之间进行了比较。
在两项研究中，所有领域的存在缺陷都与不存在缺陷分开。在第三项研究中，除了认知之外，所有领域都存在分离。在每项研究中都保留了三个主要维度；然而，领域的分配维度不同。移动能力与能量和/或力量的聚类在研究中是一致的。缺陷与年龄较大、女性性别和残疾有关。
我们的结果表明，虚弱是一个多维概念，不同人群特征下，领域之间的关系也不同。这些领域，除了认知之外，似乎聚集在一起，共享一个共同的潜在结构。
