Bergman Howard, Ferrucci Luigi, Guralnik Jack, Hogan David B, Hummel Silvia, Karunananthan Sathya, Wolfson Christina
Division of Geriatric Medicine, Jewish General Hospital/McGill University, 3755 Côte-Ste-Catherine, Montreal, Qc, Canada H3T 1E2.
J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):731-7. doi: 10.1093/gerona/62.7.731.
Clinicians and researchers have shown increasing interest in frailty. Yet, there is still considerable uncertainty regarding the concept and its definition. In this article, we present perspectives on key issues and controversies discussed by scientists from 13 different countries, representing a diverse range of disciplines, at the 2006 Second International Working Meeting on Frailty and Aging. The following fundamental questions are discussed: What is the distinction, if any, between frailty and aging? What is its relationship with chronic disease? Is frailty a syndrome or a series of age-related impairments that predict adverse outcomes? What are the critical domains in its operational definition? Is frailty a useful concept? The implications of different models and approaches are examined. Although consensus has yet to be attained, work accomplished to date has opened exciting new horizons. The article concludes with suggested directions for future research.
临床医生和研究人员对衰弱的兴趣日益浓厚。然而，关于这一概念及其定义仍存在相当大的不确定性。在本文中，我们呈现了来自13个不同国家、代表多种学科的科学家在2006年第二届衰弱与衰老国际工作会议上所讨论的关键问题和争议的观点。讨论了以下基本问题：衰弱与衰老之间（若有区别）的区别是什么？它与慢性病的关系是怎样的？衰弱是一种综合征还是一系列预测不良后果的与年龄相关的损伤？其操作定义中的关键领域有哪些？衰弱是一个有用的概念吗？研究了不同模型和方法的影响。尽管尚未达成共识，但迄今为止所完成的工作已经开启了令人兴奋的新视野。文章最后给出了未来研究的建议方向。
