Infectious Unit and University of Genoa, G. Gaslini Scientific Institute, Largo G. Gaslini 5, 16147 Genoa, Italy.
Int J Infect Dis. 2010 Feb;14(2):e167-70. doi: 10.1016/j.ijid.2009.03.025. Epub 2009 Oct 31.
Disseminated disease caused by non-tuberculous, environmental mycobacteria (EM) reflects impaired host immunity. Disseminated disease caused by Mycobacterium scrofulaceum has primarily been reported in patients with AIDS. Moreover, observing M. scrofulaceum as the agent of localized disease in childhood has become increasingly rare. We report the first case of disseminated disease caused by M. scrofulaceum in a child with inherited interferon-gamma receptor 1 (IFN-gammaR1) complete deficiency. As in this case, mycobacterial bone infections in IFN-gammaR1 deficiency can sometimes mimic the clinical picture of chronic recurrent multifocal osteomyelitis.
非结核性、环境分枝杆菌（EM）引起的播散性疾病反映了宿主免疫受损。由瘰疬分枝杆菌引起的播散性疾病主要见于艾滋病患者。此外，在儿童中观察到的由瘰疬分枝杆菌引起的局限性疾病越来越少见。我们报告了首例儿童遗传性干扰素-γ受体 1（IFN-γR1）完全缺陷引起的播散性瘰疬分枝杆菌病。在这种情况下，IFN-γR1 缺陷中的分枝杆菌骨感染有时可模拟慢性复发性多灶性骨髓炎的临床表现。
