Szilagyi Andrew, Shrier Ian, Chong George, Je Jung Sung, Park Sunghoon, Heilpern Debra, Lalonde Catherine, Cote Louis-Francois, Lee Byong
Division of Gastroenterology, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University School of Medicine, Montreal, Canada.
Can J Gastroenterol. 2009 Nov;23(11):753-9. doi: 10.1155/2009/693794.
The genetics of intestinal lactase divide the world's population into two phenotypes: the ability (a dominant trait) or inability (a recessive trait) to digest lactose. A prebiotic effect of lactose may impact the colonic flora of these phenotypes differently.
To detect and evaluate the effects of lactose on subjects divided according to their ability to digest lactose.
A total of 57 healthy maldigesters (n=30) and digesters (n=27) completed diet questionnaires, genetic and breath hydrogen testing, and quantitative stool analysis for species of bacteria. Log10 transformation of bacterial counts was compared with lactose intake in both groups using multiple regression analysis.
There was a significant relationship between genetic and breath hydrogen tests. Daily lactose intake was marginally lower in lactose maldigesters (median [interquartile range] 12.2 g [31 g] versus 15 g [29.6 g], respectively). There was no relationship between lactose intake and breath hydrogen tests in either group. There were no differences in bacterial counts between the two groups, nor was there a relationship between bacterial counts and lactose intake in either group.
The differential bacterial effects of lactose were not quantitatively detected in stool samples taken in the present study.
肠道乳糖酶的遗传学特征将世界人口分为两种表型：能够消化乳糖（显性性状）或不能消化乳糖（隐性性状）。乳糖的益生元效应可能对这些表型的结肠菌群产生不同影响。
检测并评估乳糖对根据乳糖消化能力划分的受试者的影响。
共有57名健康的乳糖消化不良者（n = 30）和乳糖消化者（n = 27）完成了饮食问卷、基因检测、呼气氢检测以及对细菌种类的定量粪便分析。使用多元回归分析比较两组中细菌计数的对数转换值与乳糖摄入量。
基因检测与呼气氢检测之间存在显著关系。乳糖消化不良者的每日乳糖摄入量略低（中位数[四分位间距]分别为12.2 g [31 g]和15 g [29.6 g]）。两组中乳糖摄入量与呼气氢检测之间均无关系。两组之间的细菌计数无差异，且两组中细菌计数与乳糖摄入量之间均无关系。
在本研究采集的粪便样本中未定量检测到乳糖对细菌的不同影响。
