从亚利桑那州一名人类身上分离出的土拉弗朗西斯菌新凶手亚种。
Francisella tularensis subsp. novicida isolated from a human in Arizona.
作者信息
Birdsell Dawn N, Stewart Tasha, Vogler Amy J, Lawaczeck Elisabeth, Diggs Alisa, Sylvester Tammy L, Buchhagen Jordan L, Auerbach Raymond K, Keim Paul, Wagner David M
机构信息
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011-4073, USA.
出版信息
BMC Res Notes. 2009 Nov 6;2:223. doi: 10.1186/1756-0500-2-223.
BACKGROUND
Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that differ in virulence and geographical distribution are recognized:tularensis (type A), holarctica (type B), mediasiatica, and novicida. Because of the Select Agent status and differences in virulence and geographical location, the molecular analysis of any clinical case of tularemia is of particular interest. We analyzed an unusual Francisella clinical isolate from a human infection in Arizona using multiple DNA-based approaches.
FINDINGS
We report that the isolate is F. tularensis subsp. novicida, a subspecies that is rarely isolated.
CONCLUSION
The rarity of this novicida subspecies in clinical settings makes each case study important for our understanding of its role in disease and its genetic relationship with other F. tularensis subspecies.
背景
土拉弗朗西斯菌是兔热病的病原体，被美国疾病控制与预防中心列为特定病原体。目前已知土拉弗朗西斯菌有四个亚种，它们在毒力和地理分布上存在差异，分别是：tularensis（A型）、holarctica（B型）、mediasiatica和novicida。由于其特定病原体地位以及毒力和地理位置的差异，对任何兔热病临床病例进行分子分析都具有特殊意义。我们使用多种基于DNA的方法分析了从亚利桑那州一名人类感染患者身上分离出的一株不寻常的弗朗西斯菌临床菌株。
研究结果
我们报告该菌株为土拉弗朗西斯菌novicida亚种，这是一种很少被分离到的亚种。
结论
这种novicida亚种在临床环境中很罕见，因此每个病例研究对于我们了解其在疾病中的作用以及它与其他土拉弗朗西斯菌亚种的遗传关系都很重要。
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