Bruns W
Z Gesamte Inn Med. 1977 May 1;32(9):133-7.
At first the review deals with significance of the apoproteins for the metabolism of the lipoproteins, especially VLDL. Thus, for instance the apo-C is a cofactor for the lipase of the fatty tissue which hydrolyses the chylomicron-TG. The author enters examples of the secondary hyperlipoproteinaemias: hyperlipoproteinaemias in diseases of the liver and of the kidneys, in pancreatitis and in diabetes. In cholestasis an abnormal lipoprotein called LP-X is observed, in other diseases of the liver the beta2LP corresponding to the VLDL-intermediate. Causes for increases of lipoproteins in renal diseases are probably disturbances of the protein metabolism. There are close correlations between hyperlipoproteinaemias and pancreatitis. In diabetes primary hyperlipoproteinaemias in maturity-onset-diabetes are to be differed from clearly secondary ones in juvenile-onset-diabetes as well as such ones in nephropathy. The therapy of the secondary hyperlipoproteinaemias is shortly discussed.
首先，该综述探讨了载脂蛋白对脂蛋白代谢的重要性，尤其是对极低密度脂蛋白（VLDL）代谢的重要性。例如，载脂蛋白C是脂肪组织中脂肪酶的辅因子，该脂肪酶可水解乳糜微粒甘油三酯（TG）。作者列举了继发性高脂蛋白血症的例子：肝脏和肾脏疾病、胰腺炎及糖尿病中的高脂蛋白血症。在胆汁淤积时，可观察到一种名为LP-X的异常脂蛋白，在其他肝脏疾病中，可观察到与VLDL中间体相对应的β2LP。肾脏疾病中脂蛋白升高的原因可能是蛋白质代谢紊乱。高脂蛋白血症与胰腺炎之间存在密切关联。在糖尿病中，成年型糖尿病的原发性高脂蛋白血症与青少年型糖尿病以及肾病中的明显继发性高脂蛋白血症有所不同。文中简要讨论了继发性高脂蛋白血症的治疗方法。
