• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用先进的临床决策支持系统实现药物选择个性化。

Personalizing Drug Selection Using Advanced Clinical Decision Support.

作者信息

Pestian John, Spencer Malik, Matykiewicz Pawel, Zhang Kejian, Vinks Alexander A, Glauser Tracy

机构信息

Clinical Linguistic Group, Division of Biomedical Informatics. Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229.

出版信息

Biomed Inform Insights. 2009 Jun 23;2:19-29. doi: 10.4137/bii.s2506.

DOI:10.4137/bii.s2506
PMID:19898682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2773552/
Abstract

This article describes the process of developing an advanced pharmacogenetics clinical decision support at one of the United States' leading pediatric academic medical centers. This system, called CHRISTINE, combines clinical and genetic data to identify the optimal drug therapy when treating patients with epilepsy or Attention Deficit Hyperactivity Disorder. In the discussion a description of clinical decision support systems is provided, along with an overview of neurocognitive computing and how it is applied in this setting.

摘要

本文介绍了美国一家领先的儿科学术医疗中心开发先进药物遗传学临床决策支持系统的过程。这个名为CHRISTINE的系统结合了临床和基因数据，以确定治疗癫痫或注意力缺陷多动障碍患者时的最佳药物治疗方案。在讨论中，提供了临床决策支持系统的描述，以及神经认知计算的概述及其在这种情况下的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/e5ff4002dd94/10.4137_BII.S2506-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/c46d6523813a/10.4137_BII.S2506-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/c3a35b81b172/10.4137_BII.S2506-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/b97a8c3a38c9/10.4137_BII.S2506-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/37a864ef140f/10.4137_BII.S2506-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/e5ff4002dd94/10.4137_BII.S2506-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/c46d6523813a/10.4137_BII.S2506-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/c3a35b81b172/10.4137_BII.S2506-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/b97a8c3a38c9/10.4137_BII.S2506-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/37a864ef140f/10.4137_BII.S2506-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e021/7492859/e5ff4002dd94/10.4137_BII.S2506-fig5.jpg

相似文献

1
Personalizing Drug Selection Using Advanced Clinical Decision Support.使用先进的临床决策支持系统实现药物选择个性化。
Biomed Inform Insights. 2009 Jun 23;2:19-29. doi: 10.4137/bii.s2506.
2
Psychiatric pharmacogenetics: personalizing psychostimulant therapy in attention-deficit/hyperactivity disorder.精神科药物遗传学：在注意缺陷多动障碍中实现精神兴奋剂治疗的个体化
Behav Brain Res. 2002 Mar 10;130(1-2):85-90. doi: 10.1016/s0166-4328(01)00436-3.
3
Pharmacogenetics Clinical Decision Support Systems for Primary Care in England: Co-Design Study.英国初级医疗中药物遗传学临床决策支持系统：共同设计研究。
J Med Internet Res. 2024 Jul 23;26:e49230. doi: 10.2196/49230.
4
Pharmacological treatment of attention-deficit/hyperactivity disorder in children and adolescents with epilepsy.儿童和青少年癫痫患者注意缺陷多动障碍的药物治疗。
Rev Neurol (Paris). 2019 Mar;175(3):141-143. doi: 10.1016/j.neurol.2018.11.003. Epub 2019 Jan 18.
5
The pharmacogenomic era: promise for personalizing attention deficit hyperactivity disorder therapy.药物基因组学时代：实现注意力缺陷多动障碍个性化治疗的希望。
Child Adolesc Psychiatr Clin N Am. 2008 Apr;17(2):475-90, xi-xii. doi: 10.1016/j.chc.2007.11.009.
6
Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital.回顾性分析一家学术儿童医院的药物遗传学检测。
Clin Transl Sci. 2021 Jan;14(1):412-421. doi: 10.1111/cts.12895. Epub 2020 Oct 15.
7
Pharmacogenomics: personalizing drug therapy.药物基因组学：个性化药物治疗。
Am J Nurs. 2009 Oct;109(10):50-7; quiz 58. doi: 10.1097/01.NAJ.0000361493.75589.06.
8
9
Stimulant Therapy Utilization for Neurocognitive Deficits in Mild Traumatic Brain Injury.刺激疗法在轻度创伤性脑损伤的神经认知缺陷中的应用。
Sports Health. 2022 Jul-Aug;14(4):538-548. doi: 10.1177/19417381211031842. Epub 2021 Jul 22.
10
A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder.神经计算模型对奖励和新颖性处理的解释以及精神兴奋剂对注意缺陷多动障碍的影响。
Brain. 2018 May 1;141(5):1545-1557. doi: 10.1093/brain/awy048.

引用本文的文献

1
Understanding the relevance of herb-drug interaction studies with special focus on interplays: a prerequisite for integrative medicine.理解草药-药物相互作用研究的相关性，尤其关注相互作用：这是整合医学的一个先决条件。
Porto Biomed J. 2019 Mar 1;4(2):e15. doi: 10.1016/j.pbj.0000000000000015. eCollection 2019 Mar-Apr.
2
Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome.预先获取遗传药理学信息对临床结果的益处。
Clin Pharmacol Ther. 2018 May;103(5):787-794. doi: 10.1002/cpt.1035. Epub 2018 Mar 13.
3
Epilepsy Treatment: A Futurist View.

本文引用的文献

1
Clinical decision support systems: Important tools when appropriately used.临床决策支持系统：恰当使用时的重要工具。
Pediatr Crit Care Med. 2009 Jan;10(1):128-9. doi: 10.1097/PCC.0b013e31819838f9.
2
From data interoperability to value-driven healthcare.从数据互操作性到价值驱动型医疗保健。
Tenn Med. 2008 Dec;101(12):31.
3
Clinical decision support systems in the pediatric intensive care unit.儿科重症监护病房中的临床决策支持系统。
癫痫治疗：未来主义视角
Epilepsy Curr. 2017 Jul-Aug;17(4):204-213. doi: 10.5698/1535-7597.17.4.204.
4
Clinical Pharmacogenetics of Cytochrome P450-Associated Drugs in Children.儿童中细胞色素P450相关药物的临床药物遗传学
J Pers Med. 2017 Nov 2;7(4):14. doi: 10.3390/jpm7040014.
5
The reliability of an epilepsy treatment clinical decision support system.癫痫治疗临床决策支持系统的可靠性
J Med Syst. 2014 Oct;38(10):119. doi: 10.1007/s10916-014-0119-9. Epub 2014 Aug 3.
6
Paediatric models in motion: requirements for model-based decision support at the bedside.动态儿科模型：床边基于模型的决策支持的要求。
Br J Clin Pharmacol. 2015 Jan;79(1):85-96. doi: 10.1111/bcp.12287.
7
Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG).儿童难治性癫痫持续状态研究中的差距和机遇：儿科癫痫持续状态研究组（pSERG）的多中心方法。
Seizure. 2014 Feb;23(2):87-97. doi: 10.1016/j.seizure.2013.10.004. Epub 2013 Oct 16.
8
NINDS epilepsy and autism spectrum disorders workshop report.NINDS 癫痫与自闭症谱系障碍研讨会报告。
Neurology. 2013 Oct 29;81(18):1630-6. doi: 10.1212/WNL.0b013e3182a9f482. Epub 2013 Oct 2.
9
Management of childhood epilepsy.儿童癫痫的管理
Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):656-81. doi: 10.1212/01.CON.0000431381.29308.85.
10
What's In a Note: Construction of a Suicide Note Corpus.遗书里有什么：自杀遗书语料库的构建
Biomed Inform Insights. 2012;5:1-6. doi: 10.4137/BII.S10213. Epub 2012 Nov 5.
Pediatr Crit Care Med. 2009 Jan;10(1):23-8. doi: 10.1097/PCC.0b013e3181936b23.
4
The role of laboratory information systems in healthcare quality improvement.实验室信息系统在医疗质量改进中的作用。
Int J Health Care Qual Assur. 2008;21(7):679-91. doi: 10.1108/09526860810910159.
5
Making us smart: why the design of clinical decision support systems is so critical.让我们变得聪明：为何临床决策支持系统的设计如此关键。
Laryngoscope. 2008 Dec;118(12):2121-4. doi: 10.1097/MLG.0b013e31818ee143.
6
An architecture for linking medical decision-support applications to clinical databases and its evaluation.一种将医学决策支持应用程序与临床数据库相连接的架构及其评估。
J Biomed Inform. 2009 Apr;42(2):203-18. doi: 10.1016/j.jbi.2008.10.007. Epub 2008 Nov 7.
7
Neurolinguistic approach to natural language processing with applications to medical text analysis.用于医学文本分析的神经语言学自然语言处理方法。
Neural Netw. 2008 Dec;21(10):1500-10. doi: 10.1016/j.neunet.2008.05.008. Epub 2008 Jun 7.
8
Event-related potentials and recognition memory.事件相关电位与识别记忆。
Trends Cogn Sci. 2007 Jun;11(6):251-7. doi: 10.1016/j.tics.2007.04.004. Epub 2007 May 3.
9
Educating health-care professionals about genetics and genomics.对医疗保健专业人员进行遗传学和基因组学教育。
Nat Rev Genet. 2007 Feb;8(2):151-7. doi: 10.1038/nrg2007.
10
Pharmacogenetics-based new therapeutic concepts.基于药物遗传学的新治疗理念。
Drug Metab Rev. 2004 Oct;36(3-4):617-38. doi: 10.1081/dmr-200033458.