贯叶金丝桃中环烯醚萜苷类化合物和保肝成分研究

Chromone glycosides and hepatoprotective constituents of Hypericum erectum.

机构信息

Key Laboratory of Organism Functional Factors of the Changbai Mountain, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.

出版信息

Arch Pharm Res. 2009 Oct;32(10):1393-7. doi: 10.1007/s12272-009-2008-1. Epub 2009 Nov 8.

DOI:10.1007/s12272-009-2008-1

PMID:19898802

Abstract

Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM and 217.7 +/- 1.3 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.

摘要

从直立金丝桃全草的甲醇提取物中分离得到了两个色酮糖苷，即 hyperimone A [7-(β-D-吡喃葡萄糖基氧基)-5-羟基-2-(1-甲基乙基)-4H-1-苯并吡喃-4-酮（1）]和 hyperimone B [7-(β-D-吡喃葡萄糖基氧基)-5-羟基-3-甲基-4H-1-苯并吡喃-4-酮（2）]，以及另外六个已知化合物。1,3,5,6-四羟基黄烷酮（5）和 I3, II8-二芹菜素（6）对 tacrine 诱导的 HepG2 细胞毒性表现出中等的肝保护活性，其 EC（50）值分别为 160.2 ± 0.6 μM 和 217.7 ± 1.3 μM。