Key Laboratory of Organism Functional Factors of the Changbai Mountain, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
Arch Pharm Res. 2009 Oct;32(10):1393-7. doi: 10.1007/s12272-009-2008-1. Epub 2009 Nov 8.
Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM and 217.7 +/- 1.3 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
从直立金丝桃全草的甲醇提取物中分离得到了两个色酮糖苷，即 hyperimone A [7-(β-D-吡喃葡萄糖基氧基)-5-羟基-2-(1-甲基乙基)-4H-1-苯并吡喃-4-酮（1）]和 hyperimone B [7-(β-D-吡喃葡萄糖基氧基)-5-羟基-3-甲基-4H-1-苯并吡喃-4-酮（2）]，以及另外六个已知化合物。1,3,5,6-四羟基黄烷酮（5）和 I3, II8-二芹菜素（6）对 tacrine 诱导的 HepG2 细胞毒性表现出中等的肝保护活性，其 EC（50）值分别为 160.2 ± 0.6 μM 和 217.7 ± 1.3 μM。
