乌苏里珍珠菜中亚种的多环多聚异戊烯基酰基间苯三酚和色酮 O-葡萄糖苷。
Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China.
出版信息
Chem Biodivers. 2010 Jan;7(1):196-204. doi: 10.1002/cbdv.200900009.
Two new C(30)-epimeric polycyclic polyprenylated acylphloroglucinols (PPAPs), named uralodins B and C (1 and 2, resp.), were isolated from the aerial parts of Hypericum henryi subsp. uraloides together with two new chromone glucosides, urachromones A and B (3 and 4, resp.), as well as 16 known compounds. Their structures were established by extensive NMR techniques and MS analysis. The epimers 1 and 2 always behaved like a single compound when examined by TLC, and were separated by HPLC. Their configuration was distinguished by comparative analysis of the NMR data with known analogues together with the ROESY experiment. All the isolated PPAPs were evaluated for their cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines. Compound 1 showed modest cytotoxic activities against SGC7901 and HL-60 cell lines, and 2 showed modest cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines.
从亨氏贯叶金丝桃亚亚种（Hypericum henryi subsp. uraloides）的地上部分分离得到两个新的 C(30)-差向异构多环聚异戊烯基酰基间苯三酚（PPAPs），分别命名为 uralodins B 和 C（1 和 2），以及两个新的色酮葡萄糖苷，uralachromes A 和 B（3 和 4），以及 16 种已知化合物。通过广泛的 NMR 技术和 MS 分析确定了它们的结构。在 TLC 检查时，差向异构体 1 和 2 总是表现为单一化合物，并用 HPLC 分离。通过与已知类似物的 NMR 数据的比较分析以及 ROESY 实验，区分了它们的构型。所有分离得到的 PPAPs 均对 HepG2、SGC7901、HL-60 和 K562 细胞系进行了细胞毒性活性评估。化合物 1 对 SGC7901 和 HL-60 细胞系表现出适度的细胞毒性活性，而 2 对 HepG2、SGC7901、HL-60 和 K562 细胞系表现出适度的细胞毒性活性。
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