手性联吡啶单氮氧（PINDOX）催化四氯化硅对中环环氧的去对称化反应。
Desymmetrization of cyclic meso-epoxides with silicon tetrachloride catalyzed by PINDOX, a chiral bipyridine mono-N-oxide.
机构信息
Department of Chemistry, WestChem, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
出版信息
Org Lett. 2009 Dec 3;11(23):5390-3. doi: 10.1021/ol902148s.
PMID:19899747
Abstract
PINDOX 8 has been identified as a chiral organocatalyst for the enantioselective ring-opening of cyclic meso-epoxides with SiCl(4) to produce chlorohydrins in up to 90% ee. The catalyst is most effective with saturated cyclic substrates containing more than seven carbon units.
摘要
PINDOX 8 已被鉴定为一种手性有机催化剂，可用于对映选择性开环环状内消旋-环氧乙烷与 SiCl(4)反应，以高达 90%的对映体过量值（ee）生成氯代醇。该催化剂对含有超过七个碳原子的饱和环状底物最有效。
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