铟-联吡啶催化的内消旋环氧化合物的对映选择性硫解反应。

Indium-bipyridine-catalyzed, enantioselective thiolysis of meso-epoxides.

作者信息

Nandakumar Mecheril Valsan, Tschöp Andreas, Krautscheid Harald, Schneider Christoph

机构信息

Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.

出版信息

Chem Commun (Camb). 2007 Jul 14(26):2756-8. doi: 10.1039/b703625f. Epub 2007 Apr 24.

DOI:10.1039/b703625f

PMID:17594044

Abstract

The indium-bipyridine-catalyzed, enantioselective ring-opening of meso-epoxides with aliphatic and aromatic thiols furnished 1,2-mercapto alcohols in good yields and excellent enantioselectivities; the crystal structure of the chiral catalyst reveals a pentagonal-bipyramidal coordination geometry around the indium center.

摘要

铟-联吡啶催化的内消旋环氧化合物与脂肪族和芳香族硫醇的对映选择性开环反应，以良好的产率和优异的对映选择性得到了1,2-巯基醇；手性催化剂的晶体结构揭示了铟中心周围的五角双锥配位几何结构。