姜黄素治疗β-地中海贫血/HbE 患者的氧化应激和抗氧化参数的改善。
Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids.
机构信息
Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.
出版信息
Clin Biochem. 2010 Mar;43(4-5):424-9. doi: 10.1016/j.clinbiochem.2009.10.057. Epub 2009 Nov 10.
OBJECTIVES
To evaluate the hematological profile, oxidative stress, and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids for 12 months.
DESIGN AND METHODS
Twenty-one beta-thalassemia/Hb E patients were given 2 capsules of 250 mg each of curcuminoids (a total of 500 mg) daily for 12 months. Blood was collected every 2 months during treatment and 3 months after withdrawal and was determined for complete blood count, malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) in red blood cells (RBC), and non-transferrin bound iron (NTBI) in serum.
RESULTS
The increased oxidative stress in beta-thalassemia/Hb E patients was shown by higher levels of MDA, SOD, GSH-Px in RBC, serum NTBI, and lower level of RBC GSH. Curcuminoids administration resulted in improvement of all the measured parameters as long as they were administered. After 3 months withdrawal of treatment, all parameters returned close to baseline levels.
CONCLUSION
Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.
目的
评估用姜黄素治疗 12 个月的β-地中海贫血/血红蛋白 E 患者的血液学特征、氧化应激和抗氧化参数。
设计和方法
21 名β-地中海贫血/血红蛋白 E 患者每天服用 2 粒 250 毫克的姜黄素（共 500 毫克），持续 12 个月。在治疗期间每 2 个月采集一次血液，并在停药后 3 个月采集一次，用于检测全血细胞计数、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、红细胞中的还原型谷胱甘肽（GSH）和血清中非转铁蛋白结合铁（NTBI）。
结果
β-地中海贫血/血红蛋白 E 患者的氧化应激增加，表现为 MDA、SOD、GSH-Px 在 RBC、血清 NTBI 中的水平升高，以及 RBC GSH 水平降低。只要给予姜黄素治疗，就能改善所有测量的参数。停药 3 个月后，所有参数均接近基线水平。
结论
姜黄素可用于改善β-地中海贫血/血红蛋白 E 疾病患者的氧化损伤。
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