Department of Infectious and Tropical Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Synapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran.
Geroscience. 2024 Jun;46(3):2933-2950. doi: 10.1007/s11357-024-01092-5. Epub 2024 Feb 27.
Aging is a gradual and irreversible process that is accompanied by an overall decline in cellular function and a significant increase in the risk of age-associated disorders. Generally, delaying aging is a more effective method than treating diseases associated with aging. Currently, researchers are focused on natural compounds and their therapeutic and health benefits. Curcumin is the main active substance that is present in turmeric, a spice that is made up of the roots and rhizomes of the Curcuma longa plant. Curcumin demonstrated a positive impact on slowing down the aging process by postponing age-related changes. This compound may have anti-aging properties by changing levels of proteins involved in the aging process, such as sirtuins and AMPK, and inhibiting pro-aging proteins, such as NF-κB and mTOR. In clinical research, this herbal compound has been extensively examined in terms of safety, efficacy, and pharmacokinetics. There are numerous effects of curcumin on mechanisms related to aging and human diseases, so we discuss many of them in detail in this review.
衰老是一个渐进的、不可逆转的过程，伴随着细胞功能的全面下降和与年龄相关疾病风险的显著增加。一般来说，延缓衰老比治疗与衰老相关的疾病更为有效。目前，研究人员专注于天然化合物及其治疗和健康益处。姜黄素是姜黄中的主要活性物质，姜黄是由姜黄植物的根和根茎制成的香料。姜黄素通过延缓与年龄相关的变化，对减缓衰老过程产生了积极影响。这种化合物可能具有抗衰老特性，通过改变参与衰老过程的蛋白质的水平，如沉默调节蛋白和 AMP 激活的蛋白激酶，以及抑制促衰老蛋白，如 NF-κB 和 mTOR。在临床研究中，这种草药化合物在安全性、疗效和药代动力学方面已经得到了广泛的研究。姜黄素对与衰老和人类疾病相关的机制有许多影响，因此我们在这篇综述中详细讨论了其中的许多影响。
