Burgess Hilary J, Kerr Moira E
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
J Vet Diagn Invest. 2009 Nov;21(6):815-20. doi: 10.1177/104063870902100607.
Co-expression of cytokeratin and vimentin has been traditionally associated with a few select tumors. However, this phenomenon is being recognized in a wider range of tumors. Twenty-one canine primary pulmonary epithelial neoplasms were evaluated for the co-expression of cytokeratin and vimentin. The histologic pattern and grade, and an immunohistochemical grade for cytokeratin and vimentin staining, were determined for each neoplasm. Adenocarcinomas predominated, and histologically, most tumors were grade II. All of the neoplasms stained positive for cytokeratin, while only 8 (38%) stained positive for both vimentin and cytokeratin. Papillary adenocarcinomas were consistently vimentin negative. The anaplastic histologic pattern had significantly more vimentin staining than the other histologic patterns. There was no significant difference in histologic grade or grading criteria between those tumors that stained with vimentin and those that did not. The present study established that cytokeratin and vimentin co-expression occurs in canine primary pulmonary epithelial tumors at a similar frequency to human pulmonary neoplasms. Further investigation will be needed to characterize the significance of this finding, particularly with respect to prognosis.
细胞角蛋白和波形蛋白的共表达传统上与少数特定肿瘤相关。然而，这种现象在更广泛的肿瘤中被认识到。对21例犬原发性肺上皮肿瘤进行了细胞角蛋白和波形蛋白共表达的评估。确定了每个肿瘤的组织学模式和分级，以及细胞角蛋白和波形蛋白染色的免疫组织化学分级。腺癌占主导，组织学上，大多数肿瘤为II级。所有肿瘤细胞角蛋白染色均为阳性，而只有8例（38%）波形蛋白和细胞角蛋白染色均为阳性。乳头状腺癌波形蛋白始终为阴性。间变组织学模式的波形蛋白染色明显多于其他组织学模式。波形蛋白染色阳性和阴性的肿瘤之间在组织学分级或分级标准上没有显著差异。本研究证实，犬原发性肺上皮肿瘤中细胞角蛋白和波形蛋白共表达的频率与人类肺肿瘤相似。需要进一步研究来确定这一发现的意义，特别是在预后方面。
