University of California, San Diego, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, School of Medicine, and Department of Gastroenterology, Rady Children's Hospital San Diego, 200 West Arbor Dr, San Diego, CA 92103-8450, USA.
Pediatrics. 2010 Oct;126(4):721-6. doi: 10.1542/peds.2009-3362. Epub 2010 Sep 20.
The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children.
A cross-sectional study of children 8 to 18 years of age was performed. Children were classified according to BMI percentile as nonobese (<95th percentile) or obese (≥95th percentile). The presence of AD36-specific neutralizing antibodies was assessed by using the serum neutralization assay.
A total of 124 children (median age: 13.6 years) were studied. Of those children, 46% were nonobese and 54% were obese. AD36 positivity was present in 19 children (15%). The majority of children found to be AD36-positive were obese (15 [78%] of 19 children). AD36 positivity was significantly (P<.05) more frequent in obese children (15 [22%] of 67 children) than nonobese children (4 [7%] of 57 children). Among the subset of children who were obese, those who were AD36-positive had significantly larger anthropometric measures, including weight, BMI, waist circumference, and waist/height ratio.
These data support an association of obesity and higher body weight with the presence of neutralizing antibodies to AD36 in children. If a cause-and-effect relationship is established, it would have considerable implications for the prevention and treatment of childhood obesity.
本研究的主要目的是评估腺病毒 36（AD36）特异性抗体与儿童肥胖之间的关系。
对 8 至 18 岁的儿童进行了横断面研究。根据 BMI 百分位将儿童分为非肥胖（<第 95 百分位）或肥胖（≥第 95 百分位）。通过血清中和试验评估 AD36 特异性中和抗体的存在。
共研究了 124 名儿童（中位数年龄：13.6 岁）。其中，46%为非肥胖，54%为肥胖。19 名儿童（15%）存在 AD36 阳性。大多数 AD36 阳性的儿童为肥胖（19 名儿童中有 15 名[78%]）。肥胖儿童中 AD36 阳性的比例明显（P<.05）高于非肥胖儿童（67 名儿童中有 15 名[22%]）。在肥胖儿童亚组中，AD36 阳性者的体重、BMI、腰围和腰高比等人体测量指标明显更大。
这些数据支持肥胖和体重增加与儿童 AD36 中和抗体的存在之间存在关联。如果确立了因果关系，将对儿童肥胖的预防和治疗产生重大影响。
