Atkinson Richard L, Lee Insil, Shin Hye-Jung, He Jia
Obetech Obesity Research Center, Richmond, VA 23219, USA.
Int J Pediatr Obes. 2010 Apr;5(2):157-60. doi: 10.3109/17477160903111789.
Human adenovirus-36 (Ad-36) is thought to induce obesity by a direct effect of the viral E4orf1 gene on lipogenic enzymes in host adipocytes. Ad-36 prevalence is 30% in obese adults, but prevalence has not been reported in childhood obesity.
To determine the prevalence of Ad-36 infection in obese Korean children (age 14.8 +/- 1.9; range 8.3-6.3 years); correlation of infection with BMI z-score and other obesity measures.
Blood was drawn at the annual school physical exam or clinic visit; Ad-36 status was determined by serum neutralization assay; and routine serum chemistry values.
A total of 30% of subjects were positive (N = 25) for Ad-36; 70% were negative (N = 59). Significantly higher BMI z-scores (1.92 vs. 1.65, p < 0.01) and waist circumferences (96.3 vs. 90.7 cm, p = 0.05) were found in infected versus uninfected children. Cardiovascular risk factors were not significantly different.
Ad-36 infection is common in obese Korean children and correlates highly with obesity. Ad-36 may have played a role in the obesity and Type 2 diabetes epidemic in children.
人腺病毒36型（Ad - 36）被认为可通过病毒E4orf1基因对宿主脂肪细胞中脂肪生成酶的直接作用来诱发肥胖。Ad - 36在肥胖成年人中的流行率为30%，但在儿童肥胖中的流行率尚未见报道。
确定肥胖韩国儿童（年龄14.8±1.9岁；范围8.3 - 16.3岁）中Ad - 36感染的流行率；感染与BMI z评分及其他肥胖指标的相关性。
在年度学校体检或门诊就诊时采集血液；通过血清中和试验确定Ad - 36状态；以及常规血清化学值。
共有30%的受试者（N = 25）Ad - 36呈阳性；70%为阴性（N = 59）。在感染儿童与未感染儿童中，发现感染儿童的BMI z评分显著更高（1.92对1.65，p < 0.01），腰围也更大（96.3对90.7厘米，p = 0.05）。心血管危险因素无显著差异。
Ad - 36感染在肥胖韩国儿童中很常见，且与肥胖高度相关。Ad - 36可能在儿童肥胖和2型糖尿病的流行中起了作用。
