Kochan T I, Eseva T V
Department of Ecological and Social Human Physiology, Institute of Physiology, Komi Research Center, Russian Academy of Sciences, Russia.
Bull Exp Biol Med. 2009 Jun;147(6):757-9. doi: 10.1007/s10517-009-0615-y.
One-year monitoring of the blood metabolic parameters in residents of the North (students aged 18-20 years and scientists aged 30-59 years) showed that blood concentrations of glucose, lactate, and albumin varied in young people (18-20 years) within a greater range throughout the year than in older subjects (30-59 years), while the range of variations for triglycerides and cholesterol concentration was lesser in young subjects. Despite age-specific differences in metabolism, the seasonal dynamics of metabolite concentrations conforms to common regularities. The contribution of anaerobic glycolysis to the maintenance of energy homeostasis is greater during the fall-winter period, which leads to reduction of glycemic level to the lowest threshold normal level and to lactatacidosis. The concentrations of triglycerides increase significantly in winter, which indicates intensification of lipogenesis. Gluconeogenesis and aerobic oxidation of reserve lipids are intensified in the winter-spring period.
对北方居民（18 - 20岁的学生和30 - 59岁的科学家）血液代谢参数进行的为期一年的监测显示，年轻人（18 - 20岁）血液中葡萄糖、乳酸和白蛋白的浓度全年变化范围比年长者（30 - 59岁）更大，而年轻受试者中甘油三酯和胆固醇浓度的变化范围较小。尽管代谢存在年龄特异性差异，但代谢物浓度的季节性动态符合一般规律。秋冬季节无氧糖酵解对维持能量稳态的贡献更大，这导致血糖水平降至最低正常阈值并引发乳酸性酸中毒。冬季甘油三酯浓度显著升高，这表明脂肪生成增强。冬春季节储备脂质的糖异生和有氧氧化增强。
