Seasonal dynamics of clinically significant metabolic parameters in northern residents of different age.

One-year monitoring of the blood metabolic parameters in residents of the North (students aged 18-20 years and scientists aged 30-59 years) showed that blood concentrations of glucose, lactate, and albumin varied in young people (18-20 years) within a greater range throughout the year than in older subjects (30-59 years), while the range of variations for triglycerides and cholesterol concentration was lesser in young subjects. Despite age-specific differences in metabolism, the seasonal dynamics of metabolite concentrations conforms to common regularities. The contribution of anaerobic glycolysis to the maintenance of energy homeostasis is greater during the fall-winter period, which leads to reduction of glycemic level to the lowest threshold normal level and to lactatacidosis. The concentrations of triglycerides increase significantly in winter, which indicates intensification of lipogenesis. Gluconeogenesis and aerobic oxidation of reserve lipids are intensified in the winter-spring period.